Acute phase reactants in nondomesticated mammals—a veterinary clinical pathology perspective

Show simple item record Hooijberg, Emma Henriette Cray, Carolyn 2022-12-06T12:38:06Z 2022-12-06T12:38:06Z 2023-02
dc.description.abstract Applications for acute phase reactants (APRs) in nondomesticated mammals include identifying inflammatory disease, monitoring the course of specific disease processes and recovery during rehabilitation, detecting preclinical or subclinical disease, being used as bioindicators for monitoring population and ecosystem health, and as markers of stress and animal welfare. Serum amyloid A, haptoglobin, C-reactive protein, fibrinogen, albumin, and iron are most commonly measured. The procedure for evaluating an APR in a nondomesticated mammalian species should follow a stepwise approach beginning with an assessment of analytical performance, followed by an evaluation of overlap performance, clinical performance, and impact on patient outcomes and management. The lack of species-specific standards and antibodies for nondomesticated mammals presents a challenge, and more attention needs to be focused on assessing cross-reactivity and ensuring adequate analytical performance of APR assays. Sample selection for the initial evaluation of APRs should consider preanalytical influences and should originate from animals with confirmed inflammatory disease and healthy animals. Reference intervals should be generated according to published guidelines. Further evaluation should focus on assessing the diagnostic utility of APRs in specific disease scenarios relevant to a species. Greater attention should be paid to assay performance and uniformity of methods when using APRs for population and ecosystem surveillance. Veterinary clinical pathologists should work closely with zoo veterinarians and wildlife researchers to optimize the accuracy and utility of APR measurements in these various conservation medicine scenarios. en_US
dc.description.department Centre for Veterinary Wildlife Studies en_US
dc.description.department Companion Animal Clinical Studies en_US
dc.description.librarian hj2022 en_US
dc.description.uri en_US
dc.identifier.citation Hooijberg, E.H. & Cray, C. Acute phase reactants in nondomesticated mammals—A veterinary clinical pathology perspective. Veterinary Clinical Pathology 2023;52(Suppl. 1):19-36. doi: 10.1111/vcp.13189. en_US
dc.identifier.issn 0275-6382 (print)
dc.identifier.issn 1939-165X (online)
dc.identifier.other 10.1111/vcp.13189
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.rights © 2022 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology. This is an open access article under the terms of the Creative Commons Attribution License. en_US
dc.subject Albumin en_US
dc.subject C-reactive protein (CRP) en_US
dc.subject Fibrinogen en_US
dc.subject Haptoglobin en_US
dc.subject Iron en_US
dc.subject Serum amyloid A en_US
dc.subject Wildlife en_US
dc.subject Zoo animals en_US
dc.subject Acute phase reactants (APRs) en_US
dc.title Acute phase reactants in nondomesticated mammals—a veterinary clinical pathology perspective en_US
dc.type Article en_US

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