Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019

Show simple item record Perovic, Olga Duse, Adrian Chibabhai, Vindana Black, Marianne Said, Mohamed Prentice, Elizabeth Wadula, Jeannette Mahabeer, Yesholata Han, Swe Swe Mogokotleng, Ruth Strasheim, Wilhelmina Lowe, Michelle Jallow, Sabelle Ismail, Husna 2022-11-02T12:49:31Z 2022-11-02T12:49:31Z 2022-08-04
dc.description.abstract OBJECTIVE : We aimed to provide an analysis of A. baumannii complex (ABC) isolated from blood cultures in South Africa. MATERIALS AND METHODS : ABC surveillance was conducted from 1 April 2017 to 30 September 2019 at 19 hospital sites from blood cultures of any age and sex. Organism identification was performed using the MALDI-TOF MS and antimicrobial susceptibility testing (AST), MicroScan Walkaway System. We confirmed colistin resistance with Sensititre, FRCOL panel, and selected for whole-genome sequencing. RESULTS : During the study period, we identified 4822 cases of ABC, of which 2152 cases were from 19 enhanced surveillance sites were reported during the enhanced surveillance period (1 August 2018 to 30 September 2019). Males accounted for 54% (2611/4822). Of the cases with known age, 41% (1968/4822) were infants (< 1-year-old). Seventy-eight percent (1688/ 2152) of cases had a known hospital outcome, of which 36% (602/1688) died. HIV status was known for 69% (1168/1688) of cases, and 14% (238/1688) were positive. Eighty-two percent (1389/1688) received antimicrobial treatment in admission. Three percent (35/ 1389) of cases received single colistin. Four percent (75/2033) were resistant to colistin. At least 75% of the isolates (1530/2033) can be classified as extensively drug-resistant (XDR), with resistance to most antibiotics except for colistin. The majority, 83% (20/24), of the colistin-resistant isolates were of the sequence type (ST) 1. Resistance genes, both plasmidand chromosomal- mediated were not observed. Although all isolates had, nine efflux pump genes related to antimicrobial resistance. CONCLUSION : Our surveillance data contributed to a better understanding of the natural course of A. baumannii disease, the patient characteristics among infants, and the level of resistance. At least two-thirds of the isolates were extensively drug-resistant, and four percent of isolates were resistant to colistin. en_US
dc.description.department Medical Microbiology en_US
dc.description.librarian dm2022 en_US
dc.description.uri en_US
dc.identifier.citation Perovic, O., Duse, A., Chibabhai, V., Black, M., Said, M., Prentice, E. et al. (2022) Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019. PLoS One 17(8): e0271355. en_US
dc.identifier.issn 1932-6203 (online)
dc.identifier.other 10.1371/ journal.pone.0271355
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2022 Perovic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. en_US
dc.subject Acinetobacter baumannii complex (ABC) en_US
dc.subject Blood cultures en_US
dc.subject South Africa (SA) en_US
dc.title Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019 en_US
dc.type Article en_US

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