The paper explores the possibility of a Reformed missional response to the present moment in Southern Africa. The basic thesis is that two of the Reformed tenets - theo-centrism and intellectual reflection as part of a holistic vocation - are especially suitable for a missional response, but stand in need of radicalising. The renaissance of trinitarian thinking and the ramifications for missiology and ecclesiology are discussed. Finally attention is given to quality improvement of theological school and the articulation of a comprehensive Reformed theology for Africa. The conviction is that these emphases will simultaneously be a turn to the material world and its challenges.