Bedaquiline and clofazimine : successes and challenges

Show simple item record Ndjeka, Norbert Ismail, Nazir Ahmed 2022-09-14T08:47:04Z 2022-09-14T08:47:04Z 2021-08
dc.description.abstract Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrugresistant tuberculosis. Both drugs have been in use in South Africa at least 10 years: bedaquiline since 2007 and clofazimine since 2010. The use of bedaquiline in programmatic settings in South Africa has reduced the risk of all-cause mortality threefold (hazard ratio 0·35, 95% CI 0·28–0·46)1 and achieved treatment success in at least 70% of patients.2 The inclusion of clofazimine in combination therapy has reduced treatment duration from 18–24 months to 9–12 months. South Africa has adopted both drugs extensively in the modified short and long regimens for rifampicin-resistant or multidrug-resistant tuberculosis. According to the electronic drug-resistant tuberculosis register, as of June 1, 2020, 29 193 individuals in South Africa have received bedaquiline, and 30 599 have received clofazimine. Emerging resistance and cross-resistance have been reported. en_US
dc.description.department Medical Microbiology en_US
dc.description.librarian am2022 en_US
dc.description.uri en_US
dc.identifier.citation Ndjeka, N. & Ismail, N.A. 2021, 'Bedaquiline and clofazimine : successes and challenges', Lancet Microbe, vol. 1, no. 4, pp. e139-e140, doi : 10.1016/S2666-5247(20)30097-5. en_US
dc.identifier.issn 2666-5247 (online)
dc.identifier.other 10.1016/S2666-5247(20)30097-5
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2020 The Author(s). This is an Open Access article under the CC BY-NC-ND 4.0 license. en_US
dc.subject Bedaquiline en_US
dc.subject Clofazimine en_US
dc.subject Resistance en_US
dc.subject South Africa (SA) en_US
dc.title Bedaquiline and clofazimine : successes and challenges en_US
dc.type Article en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record