dc.contributor.author |
Mashamba, M.A.
|
|
dc.contributor.author |
Tanser, F.
|
|
dc.contributor.author |
Afagbedzi, S.
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|
dc.contributor.author |
Beke, Andy
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|
dc.date.accessioned |
2022-09-05T12:51:28Z |
|
dc.date.available |
2022-09-05T12:51:28Z |
|
dc.date.issued |
2022-02 |
|
dc.description.abstract |
OBJECTIVE : To identify spatial clusters with unusually high levels of MDR-TB, which are highly unlikely to have arisen by chance in Mpumalanga Province, South Africa.
METHODS : Home addresses of all MDR-TB patients were collected from four MDR-TB facilities from 2013 to 2016. We mapped all addresses, linking them to the nearest ward with population estimates. A spatial analysis was conducted using kernel density in ArcGIS to estimate and map the distribution of the disease and used Gertis-Ord Gi to test for significant clustering.
RESULTS : A total of 4065 MDR-TB patients were mapped. Ten significant clusters (p-value <0.05) were found across the province in six sub-districts: Mbombela, Nkomazi, Emalahleni, Govan Mbeki, Lekwa and Mkhondo. Mbombela has the highest number of significant clusters. The central region did not have any MDR-TB clusters.
CONCLUSION : There is clear evidence of MDR-TB clustering in Mpumalanga. This calls for concentrated TB prevention efforts and proper allocation of resources. Further investigations are needed to identify MDR-TB predictors. |
en_US |
dc.description.department |
School of Health Systems and Public Health (SHSPH) |
en_US |
dc.description.librarian |
hj2022 |
en_US |
dc.description.uri |
http://www.wileyonlinelibrary.com/journal/tmi |
en_US |
dc.identifier.citation |
Mashamba, M.A., Tanser, F., Afagbedzi, S. & Beke, A. Multi-drug-resistant tuberculosis clusters in Mpumalanga province, South Africa, 2013–2016: A spatial analysis. Tropical Medicine and International Health 2022;27:185–191. https://doi.org/10.1111/tmi.13708. |
en_US |
dc.identifier.issn |
1360-2276 (print) |
|
dc.identifier.issn |
1365-3156 (online) |
|
dc.identifier.other |
10.1111/tmi.13708 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/87076 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.rights |
© 2021 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. |
en_US |
dc.subject |
Multi-drug-resistant tuberculosis (MDR-TB) |
en_US |
dc.subject |
Clustering |
en_US |
dc.subject |
Geographic information system (GIS) |
en_US |
dc.subject |
Hotspot |
en_US |
dc.subject |
Mpumalanga, South Africa |
en_US |
dc.title |
Multi-drug-resistant tuberculosis clusters in Mpumalanga province, South Africa, 2013–2016 : a spatial analysis |
en_US |
dc.type |
Article |
en_US |