• Core competencies in critical care for general medical practitioners in South Africa : a Delphi study 

  Maasdorp, S.D.; Paruk, Fathima; De Vasconcellos, K.; Grion, C.; Joubert, I.; Joynt, G.M.; Kalafatis, N.; Lapinsky, S.E.; Lipman, J.; Malbrain, M.L.N.G.; Mrara, B.; Richards, G.A.; Spruyt, M.; Van der Merwe, E.; Vincent, J.L.; Van der Merwe, L.J. (Health and Medical Publishing Group, 2023-12)

  BACKGROUND : Despite a high burden of disease that requires critical care services, there are a limited number of intensivists in South Africa (SA). Medical practitioners at district and regional public sector hospitals ...
• Clinical efficacy and safety of a novel antifungal, Fosmanogepix, in patients with candidemia caused by Candida auris : results from a Phase 2 trial 

  Vazquez, Jose A.; Pappas, Peter G.; Boffard, Kenneth D.; Paruk, Fathima; Bien, Paul A.; Tawadrous, Margaret; Ople, Eric; Wedel, Pamela; Oborska, Iwona; Hodges, Michael R. (American Society for Microbiology, 2023-04)

  Fosmanogepix (FMGX), a novel antifungal available in intravenous (IV) and oral formulations, has broad-spectrum activity against pathogenic yeasts and molds, including fungi resistant to standard of care antifungals. This ...
• Decreased severity of disease during the first global Omicron variant COVID-19 outbreak in a large hospital in Tshwane, South Africa 

  Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, W.G. (Wesley); Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)

  INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
• Predictors of in-hospital mortality among HIV-positive patients presenting with an acute illness to the emergency department 

  Laher, Abdullah E.; Paruk, Fathima; Venter, Willem Daniel Francois; Ayeni, Oluwatosin A.; Richards, Guy A. (Wiley, 2021-08)

  OBJECTIVES : Despite better access to antiretroviral therapy (ART) over recent years, HIV remains a major global cause of mortality. The present study aimed to identify predictors of in-hospital mortality among HIV-positive ...
• Development and internal validation of the HIV In-hospital mortality prediction (HIV-IMP) risk score 

  Laher, Abdullah E.; Paruk, Fathima; Venter, Willem Daniel Francois; Ayeni, Oluwatosin A.; Motara, Feroza; Moolla, Muhammed; Richards, Guy A. (Wiley, 2022-01)

  BACKGROUND : Despite advances in availability and access to antiretroviral therapy (ART), HIV still ranks as a major cause of global mortality. Hence, the aim of this study was to develop and internally validate a risk ...
• Antiretroviral therapy non-adherence among HIV- positive patients presenting to an emergency department in Johannesburg, South Africa: associations and reasons 

  Laher, Abdullah E.; Richards, G.A.; Paruk, Fathima; Venter, Willem Daniel Francois (Health and Medical Publishing Group, 2021-08)

  BACKGROUND. Suboptimal antiretroviral therapy (ART) adherence is associated with viral resistance, opportunistic infections and increased mortality. OBJECTIVES. To determine the rates of ART non-adherence and its associations, ...
• Profile of presentation of HIV-positive patients to an emergency department in Johannesburg, South Africa 

  Laher, Abdullah E.; Venter, Willem Daniel Francois; Richards, Guy A.; Paruk, Fathima (AOSIS, 2021-01-29)

  BACKGROUND: Despite improved availability and better access to antiretroviral therapy (ART), approximately 36% of human immunodeficiency virus (HIV)-positive South Africans are still not virally suppressed. Objective: ...
• Predictors of prolonged hospital stay in HIV-positive patients presenting to the emergency department 

  Laher, Abdullah E.; Paruk, Fathima; Richards, Guy A.; Venter, Willem Daniel Francois (Public Library of Science, 2021-04)

  BACKGROUND: Prolonged hospitalization places a significant burden on healthcare resources. Compared to the general population, hospital length of stay (LOS) is generally longer in HIV-positive patients. We identified ...
• Clinical utility of the BioFire FilmArray Blood Culture Identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient 

  Rule, Roxanne; Paruk, Fathima; Becker, Piet J.; Neuhoff, Matthew; Chausse, Julian; Said, Mohamed (Public Library of Science, 2021-07)

  Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate ...
• Critical Care Society of Southern Africa adult patient blood management guidelines: 2019 Round-table meeting, CCSSA Congress, Durban, 2018 

  Wise, R.D.; De Vasconcellos, K.; Gopalan, D.; Ahmed, N.; Alli, a.; Joubert, I.; Kabambi, K.F.; Mathiva, L.R.; Mdladla, N.; Mer, M.; Miller, M.; Mrara, Busisiwe; Omar, S.; Paruk, Fathima; Richards, Guy A.; Skinner, D.; Von Rahden, R. (Health and Medical Publishing Group, 2020-07)

  The CCSSA PBM Guidelines have been developed to improve patient blood management in critically ill patients in southern Africa. These consensus recommendations are based on a rigorous process by experts in the field of ...
• The role of laboratory testing in hospitalised and critically ill COVID-19-positive patients 

  Omar, S.; Baker, D.; Siebert, R.; Joubert, I.; Levy, B.; Paruk, Fathima; Gopalan, P.D. (Health and Medical Publishing Group, 2020-07)

  The COVID-19 pandemic has placed healthcare resources around the world under immense pressure. South Africa, given the condition of its healthcare system, is particularly vulnerable. There has been much discussion around ...
• Critical care triage during the COVID-19 pandemic in South Africa : a constitutional imperative! 

  Morrow, B.M.; Gopalan, P.D.; Joubert, I.; Paruk, Fathima; Pope, A. (Health and Medical Publishing Group, 2020-12)

  Triage and rationing of scarce intensive care unit (ICU) resources are an unavoidable necessity. In routine circumstances, ICU triage is premised on the best interests of an individual patient; however, when increased ...
• The Critical Care Society of Southern Africa guidelines on the allocation of scarce critical care resources during the COVID-19 public health emergency in South Africa 

  Gopalan, P.D.; Joubert, I.A.; Paruk, Fathima; Baker, D.; Coetzee, Isabella M.; De Vasconcellos, K.; Dolo, L.M.; Levy, B.L.; Morrow, B.M.; Nel, J.M.; Omar, S.; Piercy, P.L.; Siebert, R.S.; Veldsman, L. (Health and Medical Publishing Group, 2020-08)

  We thank Singh and Moodley for their detailed commentary on the Critical Care Society of Southern Africa (CCSSA) guidelines on ‘Allocation of scarce critical care resources during the COVID-19 public health emergency in ...
• Labour epidurals in Gauteng Province, South Africa 

  Wagner, J.; Chetty, S.; Paruk, Fathima; Kamerman, P. (Health and Medical Publishing Group, 2020-05)

  BACKGROUND : Inadequately controlled labour pain is associated with numerous deleterious physiological and psychological effects. Epidural labour analgesia is accepted as the gold standard. OBJECTIVES : To establish the ...
• The Critical Care Society of Southern Africa consensus statement on ICU triage and rationing (ConICTri) 

  Joynt, G.M.; Gopalan, P.D.; Argent, A.; Chetty, S.; Wise, R.; Lai, V.K.W.; Hodgson, E.; Lee, A.; Joubert, I.; Mokgokong, S.; Tshukutsoane, S.; Richards, Guy A.; Menezes, C.; Mathivha, L.R.; Espen, B.; Levy, B.; Asante, K.; Paruk, Fathima (Health and Medical Publishing Group , 2019-08)

  BACKGROUND: In South Africa (SA), intensive care is faced with the challenge of resource scarcity as well as an increasing demand for intensive care unit (ICU) services. ICU services are expensive, and practitioners in ...
• Critically ill obstetric patients with hypertensive disorders of pregnancy : room for improvement 

  Paruk, Fathima (Health and Medical Publishing Group, 2019-12)

  Hypertensive disorders of pregnancy constitute a global problem. While they are reported to complicate 5 - 10 % of pregnancies, it is considered that the incidence is rising, owing to a number of factors including ...
• Improved understanding of the pathophysiology of sepsis : setting the scene for potential novel adjunctive therapies 

  Chausse, J.M.; Malekele, L.; Paruk, Fathima (Health and Medical Publishing Group, 2018)

  The occurrence of sepsis in the critically ill population is a dreaded phenomenon when taking into consideration the devastating complications associated with the disease. Despite its high incidence and unacceptably high ...
• Muscle strength and endurance to predict successful extubation in mechanically ventilated patients : a pilot study evaluating the utility of upper-limb muscle strength and ergometry 

  De Beer, C.R.; Van Rooijen, Agatha Johanna; Pretorius, Jan P.; Becker, Piet J.; Rheeder, Paul; Paruk, Fathima (Health and Medical Publishing Group, 2018)

  BACKGROUND. Successful extubation of mechanically ventilated patients is essential for the physiotherapist to succeed in respiratory rehabilitation of the patient. Delay in the weaning process increases the complication ...
• Starvation ketoacidosis in pregnancy presenting as euglycaemic-high anion gap metabolic acidosis : a case report highlighting the significance of early recognition and prompt intervention 

  Chausse, J.M.; Paruk, Fathima; Motilall, S.; Soma-Pillay, Priya; Ndaba, S. (Health and Medical Publishing Group, 2018-08)

  Starvation ketoacidosis (SKA) constitutes an important consideration in the pregnant patient who presents with profound metabolic acidosis. Pregnancy-related changes predispose the patient to develop SKA following relatively ...
• Glycaemic control in a cardiothoracic surgical population : exploring the protocol-practice gap 

  Maharaj, D.; Perrie, H.; Scribante, J.; Paruk, Fathima (Health and Medical Publishing Group, 2017-07)

  BACKGROUND : Glycaemic control constitutes an important component in the management of critically ill patients. As such, all healthcare workers involved in the management of critically ill patients need to ensure that ...

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