Diagnostic value of sentinel lymph node scintigraphy and 2‐[18F]‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography/computed tomography in the detection of metastatic lymph nodes in patients with early‐stage cervical cancer

Show simple item record

dc.contributor.author Reyneke, Florette
dc.contributor.author Snyman, Leon Cornelius
dc.contributor.author Lawal, Ismaheel
dc.contributor.author Lengana, Thabo
dc.date.accessioned 2021-10-14T05:39:59Z
dc.date.available 2021-10-14T05:39:59Z
dc.date.issued 2020-07
dc.description.abstract Cervical cancer is staged clinically using the International Federation of Gynaecology and Obstetrics staging system. Although lymph node status does not form part of the staging, it has important prognostic and potential therapeutic implications. The aim of the study was to evaluate the role of sentinel lymph node (SLN) scintigraphy and 2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography/computed tomography (18F‑FDG PET/CT) in detecting lymph node metastases in patients with early‑stage cervical cancer. Thirty‑six patients with early‑stage cervical cancer underwent SLN detection during primary operation. Of the 36 patients, 28 patients underwent 18F‑FDG PET/CT before surgery. The 18F‑FDG PET/CT images were analyzed with the histopathological findings as the reference standard. The diagnostic performance of 18F‑FDG PET/CT in the detection of nodal disease was reported in terms of accuracy value. The SLN detection rate was the highest (91.7%) using the combined method (lymphoscintigraphy, intraoperative gamma probe, and blue dye). Seven of the thirty‑six patients had lymph node involvement (19.4%), of which five had preoperative 18F‑FDG PET/CT imaging. On overall patient‑based analysis, the sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of 18F‑FDG PET/CT were 40.0%, 78.3%, 28.6%, 85.7%, and 71.4%, respectively. The combination of radiolabeled nanocolloid with blue dye is safe and reliable and allows successful detection of SLNs in patients with early‑stage cervical cancer in a population with high prevalence of human immunodeficiency virus. The specificity and NPV of 18F‑FDG PET/CT are high and can be used in conjunction with SLN biopsy. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.librarian pm2021 en_ZA
dc.description.uri https://www.wjnm.org en_ZA
dc.identifier.citation Reyneke F, Snyman LC, Lawal I, Lengana T, Vorster M, Sathekge M. Diagnostic value of sentinel lymph node scintigraphy and 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/ computed tomography in the detection of metastatic lymph nodes in patients with early-stage cervical cancer. World Journal of Nuclear Medicine 2020;19:240-245. en_ZA
dc.identifier.issn 1450-1147 (print)
dc.identifier.issn 1607-3312 (online)
dc.identifier.other 10.4103/wjnm.WJNM_74_19
dc.identifier.uri http://hdl.handle.net/2263/82105
dc.language.iso en en_ZA
dc.publisher Medknow Publications en_ZA
dc.rights © 2020 World Journal of Nuclear Medicine | Published by Wolters Kluwer - Medknow en_ZA
dc.subject 2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose en_ZA
dc.subject Cervical cancer en_ZA
dc.subject Sentinel lymph node (SLN) en_ZA
dc.subject Positron emission tomography/computed tomography (PET/CT) en_ZA
dc.title Diagnostic value of sentinel lymph node scintigraphy and 2‐[18F]‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography/computed tomography in the detection of metastatic lymph nodes in patients with early‐stage cervical cancer en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record