The impact of obesity on the cellular and molecular pathophysiology of COVID-19

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Authors

Dhanraj, Priyanka;
Pitere, R.
Pepper, Michael Sean

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Publisher

Health and Medical Publishing Group

Abstract

Emerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms potentially contributing to the pathophysiology of COVID-19 in obese patients. Understanding the relationship between COVID-19 and obesity is pertinent for the clinical management of these patients.

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Keywords

Obesity, Immune response, COVID-19 pandemic, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Angiotensin-converting enzyme-2 (ACE2)

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Citation

Dhanraj, P, Pitere, R & Pepper, MS 2021, 'The impact of obesity on the cellular and molecular pathophysiology of COVID-19', South African Medical Journal, vol. 111, no. 3, pp. 211-214.