Accelerated failure-time model with weighted least-squares estimation : application on survival of HIV positives

Show simple item record Mustefa, Abdela Chen, Ding-Geng (Din) 2021-08-27T06:11:12Z 2021-08-27T06:11:12Z 2021-05
dc.description.abstract BACKGROUND: Survival analysis is the most appropriate method of analysis for time-to-event data. The classical accelerated failure-time model is a more powerful and interpretable model than the Cox proportional hazards model, provided that model imposed distribution and homoscedasticity assumptions satisfied. However, most of the real data are heteroscedastic which violates the fundamental assumption and consequently, the statistical inference could be erroneous in accelerated failure-time modeling. The weighted least-squares estimation for the accelerated failure-time model is an efficient semi-parametric approach for time-to-event data without the homoscedasticity assumption, which is developed recently and not often utilized for real data analysis. Thus, this study was conducted to ascertain the better performance of the weighted least-squares estimation method over the classical methods. METHODS: We analyzed a REAL dataset on Antiretroviral Therapy patients we recently collected. We compared the results from classical methods of estimation for the accelerated failure-time model with the results revealed from the weighted least-squares estimation. RESULTS: We found that the data are heteroscedastic and indicated that the weighted least-square method should be used to analyze this data. The weighted least-squares estimation revealed more accurate, and efficient estimates of covariates effect since its confidence intervals were shorter and it identified more significant covariates. Accordingly, the survival of HIV positives was found to be significantly linked with age, weight, functional status, CD4 (Cluster of Differentiation agent 4 glycoproteins), and clinical stages. CONCLUSIONS: The weighted least-squares estimation performed the best in providing more significant effects and precise estimates than the classical accelerated failure-time methods of estimation if data are heteroscedastic. Thus, we recommend future researchers should utilize weighted least-squares estimation rather than the classical methods when the homoscedasticity assumption is violated. en_ZA
dc.description.department Statistics en_ZA
dc.description.librarian pm2021 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Mustefa, Y.A., Chen, DG. Accelerated failure-time model with weighted least-squares estimation: application on survival of HIV positives. Archives of Public Health 79, 88 (2021). en_ZA
dc.identifier.issn 0778-7367 (online)
dc.identifier.other 10.1186/s13690-021-00617-0
dc.language.iso en en_ZA
dc.publisher BMC en_ZA
dc.rights © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Survival data analysis en_ZA
dc.subject Accelerated failure-time en_ZA
dc.subject Cox proportional-hazards regression en_ZA
dc.subject Weighted leastsquares estimation en_ZA
dc.subject Heteroscedasticity en_ZA
dc.title Accelerated failure-time model with weighted least-squares estimation : application on survival of HIV positives en_ZA
dc.type Article en_ZA

Files in this item

This item appears in the following Collection(s)

Show simple item record