Abstract:
Without a doubt, potatoes play a vital food and nutrition security role in the world as
more than a billion people consume this vegetable. Furthermore, the polyphenolic constituents of
pigmented potato cultivars and their associated health benefits have been reported. However, the
antioxidant, anticancer, and antimycobacterial activity of pigmented cultivars are scanty. Therefore, the present study explores the phenolic acids and biological activities of cv. Salad Blue
(SB) and non-pigmented control (BP1) extracts. The antiproliferative activity of S. tuberosum L.
against human hepatocellular carcinoma (HepG2) was investigated, as well as the ability to inhibit
Mycobacterium smegmatis. Chlorogenic acid was the most prominent phenolic acid in both treatments
as well as cultivars. In the current trial, 24 ◦C significantly increased chlorogenic acid in cv. SB and
BP1. Ethanolic extracts of all the samples showed no activity at the highest test concentration of
1000 µg/mL (ciprofloxacin MIC of 0.325 µg/mL) against M. smegmatis. The antiproliferative activity
of the tuber samples against HepG2 liver cells had IC50 values ranging between 267.7 ± 36.17 µg/mL
and >400 µg/mL. Since the health benefits of these cultivars are highly valued, the present study
provides useful information for future oncology studies, for human nutrition, as well as for how
these underutilized cultivars can be fortified to improve their health benefits.
