Trends in population dynamics of Escherichia coli sequence type 131, Calgary, Alberta, Canada, 2006–2016

Show simple item record Peirano, G. Lynch, T. Finn, T.J. De Vinney, R. Pitout, Johann D.D. Matsumara, Y. Nobrega, D. 2021-06-25T09:47:37Z 2021-06-25T09:47:37Z 2020-12
dc.description.abstract Global expansion of antimicrobial drug–resistant Escherichia coli sequence type (ST) 131 is unrivaled among human bacteria. Understanding trends among ST131 clades will help with designing prevention strategies. We screened E. coli from blood samples (n = 1,784) obtained in Calgary, Alberta, Canada, during 2006, 2012, and 2016 by PCR for ST131 and positive samples (n = 344) underwent whole-genome sequencing. The incidence rate per 100,000 residents increased from 4.91 during 2006 to 12.35 during 2012 and 10.12 during 2016. ST131 belonged to clades A (10%), B (9%), and C (81%). Clades C1-nonM27 and B were common during 2006, and C2 containing blaCTX-M-15, C1-M27 containing blaCTXM-27, and A were responsible for the increase of ST131 during 2012 and 2016. C2 was the most antimicrobial drug–resistant subclade and increased exponentially over time. Eradicating ST131, more specifically the C2 subclade, will lead to considerable public health benefits for persons in Calgary. en_ZA
dc.description.department Medical Microbiology en_ZA
dc.description.librarian pm2021 en_ZA
dc.description.sponsorship The Joint Programming Initiative on Antimicrobial Resistance/Canadian Institute Health Research Program. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Peirano G, Lynch T, Matsumara Y, Nobrega D, Finn TJ, DeVinney R, Pitout JDD. Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006-20161. Emerging Infectious Diseases 2020 Dec;26(12):2907-2915. doi: 10.3201/eid2612.201221. en_ZA
dc.identifier.issn 1080-6040 (print)
dc.identifier.issn 1080-6059 (online)
dc.identifier.other 10.3201/eid2612.201221
dc.language.iso en en_ZA
dc.publisher Centers for Disease Control and Prevention en_ZA
dc.rights © 2020, Centers for Disease Control and Prevention (CDC). All rights reserved. en_ZA
dc.subject Population dynamics en_ZA
dc.subject Escherichia coli Sequence Type 131 en_ZA
dc.subject Human bacteria en_ZA
dc.subject Prevention strategies en_ZA
dc.subject Canada en_ZA
dc.subject Public health en_ZA
dc.title Trends in population dynamics of Escherichia coli sequence type 131, Calgary, Alberta, Canada, 2006–2016 en_ZA
dc.type Article en_ZA

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