Vaccination against GnRH as a prelude to surgical castration of horses

Show simple item record Birrell, John R. Schulman, M.L. (Martin) Botha, A.E. (Alma) Ganswindt, Andre Fosgate, Geoffrey Theodore Bertschinger, Hendrik Jan 2021-05-24T09:03:51Z 2021-11
dc.description.abstract BACKGROUND : Surgical castration is one of the most frequently performed surgeries in horses and is associated with various post-surgical complications ranging in severity. OBJECTIVES : We investigated the effects of administering an anti-GnRH vaccine to colts for reduction of testis size on the incidence of complications associated with their subsequent surgical castration. STUDY DESIGN : Randomised open controlled trial. METHODS : Nineteen colts were randomly assigned to one of the three groups. Treatment Groups V1-57 and V2-100 received two treatments of Improvac® (Zoetis, South Africa) before their castration in the field on either Day 57 or Day 100 following first treatment, respectively. Controls similarly received placebo treatments followed by castration on Day 57. Serial measurements of testicular dimensions and serum samples for measuring serum testosterone concentrations (STCs) and anti-GnRH antibody titres (ABTs) were obtained pre- and post-vaccination and on the day of castration. Clinical data recorded for 10 days determined post-surgical complications. RESULTS : All vaccinated colts showed a baseline STC concentration at castration with a strong ABT response. Mean testicular volume of Groups V1-57 and V2-100 reduced by 49.7% and 30.8%, respectively, on Day 57 and this further reduced in Group V2-100 by 63.9% at castration on Day 100. Testis size was significantly correlated with post-surgical preputial (P = 0.001) and scrotal (P = 0.025) swelling. MAIN LIMITATIONS : A study population of young light horse breed colts and a relatively small sample size limited this pilot study. en_ZA
dc.description.department Mammal Research Institute en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.embargo 2021-12-22
dc.description.librarian hj2021 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Birrell, J.R., Schulman, M.L., Botha, A.E., Ganswindt, A., Fosgate, G.T. & Bertschinger, H.J. Vaccination against GnRH as a prelude to surgical castration of horses. Equine Veterinary Journal 2021;53(6):1141-1149. doi: 10.1111/evj.13411. en_ZA
dc.identifier.issn 0425-1644 (print)
dc.identifier.issn 2042-3306 (online)
dc.identifier.other 10.1111/evj.13411
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2020 EVJ Ltd. This is the pre-peer reviewed version of the following article : (name of article), Journal name, vol. 53, no. 6, pp. 1141-1149, 2021, doi : 10.1111/evj.13411. The definite version is available at : en_ZA
dc.subject Anti-GnRH vaccine en_ZA
dc.subject Colt en_ZA
dc.subject Horse (Equus caballus) en_ZA
dc.subject Surgical castration en_ZA
dc.title Vaccination against GnRH as a prelude to surgical castration of horses en_ZA
dc.type Postprint Article en_ZA

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