The effectiveness of bFGF in the treatment of tympanic membrane perforations : a systematic review and meta-analysis

Show simple item record Huang, Juntao Teh, Bing Mei Eikelboom, Robert H. Han, Liyuan Xu, Guodong Yao, Xu Hu, Yi Zheng, Minghao Shen, Yi 2021-05-18T09:26:34Z 2021-05-18T09:26:34Z 2020
dc.description.abstract OBJECTIVE : To investigate the effectiveness of basic fibroblast growth factor (bFGF) versus placebo or no intervention in the treatment of tympanic membrane (TM) perforations from randomized controlled trials (RCTs), prospective and retrospective studies. DATA SOURCES : PubMed, EMBASE, and Cochrane databases were screened from their inceptions to June 2019. STUDY SELECTION : Inclusion criteria: 1) English language; 2) observational (retrospective or prospective) or treatment (RCT) studies; 3) reported the outcomes on the application of bFGF in adult or pediatric population. Exclusion criteria: 1) studies without a control group; 2) animal studies, in vitro studies, review studies, and case reports. DATA EXTRACTION : Number of patients, cause of TM perforation, perforation size, treatment, mean age, follow-up time, sex, closure rate, healing time, mean air-bone gap improvement. DATA SYNTHESIS : A total of 14 studies were included, including seven RCTs and seven non-RCTs with a total of 1,072 participants. The odds ratio for closure rate of bFGF treatment was 7.33 (95% confidence interval [CI], 4.65 to 11.53; p<0.01; I2¼44%) and the standardized mean difference (SMD) for healing time was –5.89 (95% CI: –7.85 to –3.93, p<0.01, I2¼98%), suggesting bFGF application has a significant effect on closure of TM perforations. However, no significant change in hearing (SMD: 0.08, 95% CI: –0.11 to 0.27, p¼0.39, I2¼0%) was seen as a result of bFGF treatment. CONCLUSIONS : Our meta-analysis has revealed that the application of bFGF can significantly enhance the closure rate as well as shorten the healing time for TM perforations. In terms of hearing, there is as yet no evidence that bFGF has a significant effect. Given its ease, availability, and safety, bFGF can be used effectively for TM repair. en_ZA
dc.description.department Speech-Language Pathology and Audiology en_ZA
dc.description.librarian am2021 en_ZA
dc.description.sponsorship The National Natural Science Foundation of China, Zhejiang Provincial Natural Science Foundation, Zhejiang Provincial Medical and Health Science Research Foundation, Ningbo Natural Science Foundation, Ningbo Huimin Technology Research and Development Project Fund and Ningbo Health Branding Subject Fund. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Huang, J., Teh, B.M., Eikelboom, R.H. et al. 2020, 'The effectiveness of bFGF in the treatment of tympanic membrane perforations : a systematic review and meta-analysis', Otology and Neurotology, vol. 41, pp. 782-790. en_ZA
dc.identifier.issn 1531-7129 (print)
dc.identifier.issn 1537-4505 (online)
dc.identifier.other 10.1097/MAO.0000000000002628
dc.language.iso en en_ZA
dc.publisher Lippincott Williams and Wilkins en_ZA
dc.rights © 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND). en_ZA
dc.subject Healing en_ZA
dc.subject Hearing en_ZA
dc.subject Meta-analysis en_ZA
dc.subject Tympanic membrane perforation en_ZA
dc.subject Basic fibroblast growth factor (bFGF) en_ZA
dc.subject Randomized controlled trial (RCT) en_ZA
dc.title The effectiveness of bFGF in the treatment of tympanic membrane perforations : a systematic review and meta-analysis en_ZA
dc.type Article en_ZA

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