Patterns of Rift Valley fever virus seropositivity in domestic ruminants in central South Africa four years after a large outbreak

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dc.contributor.author Ngoshe, Yusuf Bitrus
dc.contributor.author Avenant, Alida
dc.contributor.author Rostal, Melinda K.
dc.contributor.author Karesh, William B.
dc.contributor.author Paweska, Janusz Tadeusz
dc.contributor.author Bagge, Whitney
dc.contributor.author Jansen van Vuren, Petrus
dc.contributor.author Kemp, Alan
dc.contributor.author Cordel, Claudia
dc.contributor.author Msimang, Veerle
dc.contributor.author Thompson, P.N. (Peter N.)
dc.date.accessioned 2021-04-08T10:45:14Z
dc.date.available 2021-04-08T10:45:14Z
dc.date.issued 2020
dc.description.abstract Rift Valley fever (RVF) is a mosquito-borne viral zoonosis showing complex epidemiological patterns that are poorly understood in South Africa. Large outbreaks occur in the central interior at long, irregular intervals, most recently in 2010–2011; however, the level of herd immunity of ruminant livestock, a key determinant of outbreaks, is unknown. During 2015–2016 a cross-sectional study on 234 randomly-selected farms investigated the prevalence, patterns of, and factors associated with, antibodies to RVF virus (RVFV) in livestock in an area heavily affected by that outbreak. A RVFV inhibition ELISA was used to screen 977 cattle, 1,549 sheep and 523 goats and information on potential risk factors was collected using a comprehensive questionnaire. The estimated RVFV seroprevalence, adjusted for survey design, was 42.9% in cattle, 28.0% in sheep and 9.3% in goats, showing a high degree of farm-level clustering. Seroprevalence increased with age and was higher on private vs. communal land, on farms with seasonal pans (temporary, shallow wetlands) and perennial rivers and in recently vaccinated animals. Seropositivity amongst unvaccinated animals born after the last outbreak indicates likely viral circulation during the post-epidemic period. The current level of herd immunity in livestock may be insufficient to prevent another large outbreak, should suitable conditions recur. en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.librarian am2021 en_ZA
dc.description.sponsorship The EcoHealth Alliance, the University of Pretoria and the National Research Foundation. en_ZA
dc.description.uri http://www.nature.com/srep en_ZA
dc.identifier.citation Ngoshe, Y.B., Avenant, A., Rostal, M.K. et al. 2020, 'Patterns of Rift Valley fever virus seropositivity in domestic ruminants in central South Africa four years after a large outbreak', Scientific Reports, vol. 10, no. 1, art. 5489, pp. 1-13. en_ZA
dc.identifier.issn 2045-2322 (online)
dc.identifier.other 10.1038/s41598-020-62453-6
dc.identifier.uri http://hdl.handle.net/2263/79354
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.rights © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Livestock en_ZA
dc.subject Outbreak en_ZA
dc.subject Rift Valley fever (RVF) en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject.other Veterinary science articles SDG-3 en_ZA
dc.subject.other Veterinary science articles SDG-1 en_ZA
dc.title Patterns of Rift Valley fever virus seropositivity in domestic ruminants in central South Africa four years after a large outbreak en_ZA
dc.type Article en_ZA


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