Increases in cholecystectomy for gallstone related disease in South Africa

Show simple item record Khan, Zafar Ahmed Khan, Muhammed Uzayr Brand, Martin 2021-04-08T10:05:19Z 2021-04-08T10:05:19Z 2020-08-11
dc.description This paper draws upon the author’s thesis for a Masters in Medicine at the University of the Witwatersrand. en_ZA
dc.description.abstract Studies suggest that the rate gallstone disease in Africa is low. Previous studies suggested an increase in gallstone rates and cholecystectomies related to urbanization and the adoption of Western lifestyle habits. This study examined cholecystectomy rates for gallstone disease in South Africa (SA). An audit of cholecystectomies in SA was done by reviewing gallbladder specimens processed by the SA National Health Laboratory Service (NHLS) from 2004 and 2014. Urbanization rates were obtained from Statistics South Africa and BMI data from previously published studies. Fisher’s exact test, t test’s and Pearson’s R were used for comparisons; cholecystectomy rates were calculated per 100,000 population. 33,467 cholecystectomy specimens were analysed. There was a 92% absolute increase in cholecystectomies during the study period (Pearson r 0.94; p < 0.01) with the overall cholecystectomy rate increasing by 65% from 8.36 to 13.81 per 100,000 population. The data was divided into two equal periods and compared. During the second period there was a 28.8% increase in the number cholecystectomies and patients were significantly younger (46.9 vs 48.2 years; p ≤ 0.0001). The Northern Cape was the only province to show a decline in the cholecystectomy rate in this period and was also the only province to record a decline in urbanization. Population based studies in SA demonstrate increases in BMI and an association with increased urbanization. This nationwide African study demonstrates a sustained increase in cholecystectomies for gallstone disease. Increases in BMI and urbanization may be responsible for this trend. en_ZA
dc.description.department Surgery en_ZA
dc.description.librarian am2021 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Khan, Z.A., Khan, M.U. & Brand, M. 2020, 'Increases in cholecystectomy for gallstone related disease in South Africa', Scientific Reports, vol. 10, art. 13516, pp. 1-5. en_ZA
dc.identifier.issn 2045-2322 (online)
dc.identifier.other 10.1038/s41598-020-69812-3
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.rights © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Gallstone disease en_ZA
dc.subject Africa en_ZA
dc.subject Low en_ZA
dc.subject Urbanization en_ZA
dc.subject South Africa (SA) en_ZA
dc.title Increases in cholecystectomy for gallstone related disease in South Africa en_ZA
dc.type Article en_ZA

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