Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa

Show simple item record

dc.contributor.author Van Schalkwyk, Antoinette
dc.contributor.author Kara, Pravesh
dc.contributor.author Ebersohn, Karen
dc.contributor.author Mather, Arshad
dc.contributor.author Annandale, Cornelius Henry
dc.contributor.author Venter, Estelle Hildegard
dc.contributor.author Wallace, David Brian
dc.date.accessioned 2021-03-02T06:13:49Z
dc.date.available 2021-03-02T06:13:49Z
dc.date.issued 2020-11
dc.description.abstract South Africa is endemic for lumpy skin disease and is therefore reliant on various live attenuated vaccines for the control and prevention of the disease. In recent years, widespread outbreaks of vaccine-like strains of lumpy skin disease virus (LSDV) were reported internationally, leading to an increase in the generation of full genome sequences from field isolates. In this study, the complete genomes of six LSDVs submitted during active outbreaks in the 1990s in South Africa were generated. Based on phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup 1.1 and are subsequently referred to as vaccine-associated. The genetic differences between the phenotypically distinct vaccine and vaccine-associated strains were 67 single nucleotide polymorphisms (SNPs). This study characterized the location and possible importance of each of these SNPs in their role during virulence and host specificity. en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.department Veterinary Tropical Diseases en_ZA
dc.description.librarian am2021 en_ZA
dc.description.sponsorship The South African Gauteng Department of Agriculture and Rural Development as well as the European Union's Horizon 2020 research and innovation programme. en_ZA
dc.description.uri http://wileyonlinelibrary.com/journal/tbed en_ZA
dc.identifier.citation Van Schalkwyk A, Kara P, Ebersohn K, et al. Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa. Transboundary and Emerging Diseases 2020;67:2946–2960. https://DOI.org/10.1111/tbed.13670. en_ZA
dc.identifier.issn 1865-1674 (print)
dc.identifier.issn 1865-1682 (online)
dc.identifier.other 10.1111/tbed.13670
dc.identifier.uri http://hdl.handle.net/2263/78901
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2020 Agricultural Research Council. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. en_ZA
dc.subject Emerging diseases en_ZA
dc.subject Pathogenesis en_ZA
dc.subject Sequences en_ZA
dc.subject Vaccine en_ZA
dc.subject Virus en_ZA
dc.subject Lumpy skin disease virus (LSDV) en_ZA
dc.subject Single nucleotide polymorphism (SNP) en_ZA
dc.title Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record