Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa

Loading...
Thumbnail Image

Authors

Van Schalkwyk, Antoinette
Kara, Pravesh Deepak
Ebersohn, Karen
Mather, Arshad
Annandale, Cornelius Henry
Venter, Estelle Hildegard
Wallace, David Brian

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

South Africa is endemic for lumpy skin disease and is therefore reliant on various live attenuated vaccines for the control and prevention of the disease. In recent years, widespread outbreaks of vaccine-like strains of lumpy skin disease virus (LSDV) were reported internationally, leading to an increase in the generation of full genome sequences from field isolates. In this study, the complete genomes of six LSDVs submitted during active outbreaks in the 1990s in South Africa were generated. Based on phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup 1.1 and are subsequently referred to as vaccine-associated. The genetic differences between the phenotypically distinct vaccine and vaccine-associated strains were 67 single nucleotide polymorphisms (SNPs). This study characterized the location and possible importance of each of these SNPs in their role during virulence and host specificity.

Description

Keywords

Emerging diseases, Pathogenesis, Sequences, Vaccine, Virus, Lumpy skin disease virus (LSDV), Single nucleotide polymorphism (SNP)

Sustainable Development Goals

Citation

Van Schalkwyk A, Kara P, Ebersohn K, et al. Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa. Transboundary and Emerging Diseases 2020;67:2946–2960. https://DOI.org/10.1111/tbed.13670.