dc.contributor.author |
Van Schalkwyk, Antoinette
|
|
dc.contributor.author |
Kara, Pravesh Deepak
|
|
dc.contributor.author |
Ebersohn, Karen
|
|
dc.contributor.author |
Mather, Arshad
|
|
dc.contributor.author |
Annandale, Cornelius Henry
|
|
dc.contributor.author |
Venter, Estelle Hildegard
|
|
dc.contributor.author |
Wallace, David Brian
|
|
dc.date.accessioned |
2021-03-02T06:13:49Z |
|
dc.date.available |
2021-03-02T06:13:49Z |
|
dc.date.issued |
2020-11 |
|
dc.description.abstract |
South Africa is endemic for lumpy skin disease and is therefore reliant on various live
attenuated vaccines for the control and prevention of the disease. In recent years,
widespread outbreaks of vaccine-like strains of lumpy skin disease virus (LSDV) were
reported internationally, leading to an increase in the generation of full genome sequences
from field isolates. In this study, the complete genomes of six LSDVs submitted
during active outbreaks in the 1990s in South Africa were generated. Based on
phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup
1.1 and are subsequently referred to as vaccine-associated. The genetic differences
between the phenotypically distinct vaccine and vaccine-associated strains were 67
single nucleotide polymorphisms (SNPs). This study characterized the location and
possible importance of each of these SNPs in their role during virulence and host
specificity. |
en_ZA |
dc.description.department |
Production Animal Studies |
en_ZA |
dc.description.department |
Veterinary Tropical Diseases |
en_ZA |
dc.description.librarian |
am2021 |
en_ZA |
dc.description.sponsorship |
The South African Gauteng Department of Agriculture and Rural Development as well as the European Union's Horizon 2020 research and innovation programme. |
en_ZA |
dc.description.uri |
http://wileyonlinelibrary.com/journal/tbed |
en_ZA |
dc.identifier.citation |
Van Schalkwyk A, Kara P, Ebersohn K, et al. Potential link of single nucleotide polymorphisms to
virulence of vaccine-associated field strains of lumpy skin
disease virus in South Africa. Transboundary and Emerging Diseases
2020;67:2946–2960. https://DOI.org/10.1111/tbed.13670. |
en_ZA |
dc.identifier.issn |
1865-1674 (print) |
|
dc.identifier.issn |
1865-1682 (online) |
|
dc.identifier.other |
10.1111/tbed.13670 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/78901 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2020 Agricultural Research Council.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. |
en_ZA |
dc.subject |
Emerging diseases |
en_ZA |
dc.subject |
Pathogenesis |
en_ZA |
dc.subject |
Sequences |
en_ZA |
dc.subject |
Vaccine |
en_ZA |
dc.subject |
Virus |
en_ZA |
dc.subject |
Lumpy skin disease virus (LSDV) |
en_ZA |
dc.subject |
Single nucleotide polymorphism (SNP) |
en_ZA |
dc.title |
Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa |
en_ZA |
dc.type |
Article |
en_ZA |