The effect of methadone on blood glucose, lipids and glucose‑modulating hormones in methadone‑dependent Wistar rats

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dc.contributor.author Tahergorabi, Zoya
dc.contributor.author Rahmani, Hadiseh
dc.contributor.author Williams, J.H. (June Heather)
dc.contributor.author Moodi, Mitra
dc.date.accessioned 2021-03-02T05:23:21Z
dc.date.issued 2020-07
dc.description.abstract A growing body of evidence indicates that opioids regulate mechanisms activated during the stress response. This study was aimed to investigate the effect of methadone dependency on blood glucose, lipids and glucose-modulating hormones in male and female Wistar rats.This study was performed on 40 Wistar rats weighing 150–350 g, in four methadone exposure and control groups of both males and females. All rats were weighed at the beginning and end of the study and their fasting blood glucose was measured using a glucometer. In order to induce addiction, methadone was injected intraperitoneal for 10 consecutive days at 5 mg/kg dose. The control group received the same volume of only normal saline. At the end of the study, the rats were sacrificed and their blood serum collected to measure cortisol, glucagon, adrenaline and lipid profile levels. There was a significant decrease in the mean final blood glucose of methadone-treated versus control male rats (p = 0.02). There was no significant glucose difference, however, in female rats. Furthermore, a decrease in the mean serum levels of triglyceride, cortisol, and adrenaline occurred in male rats of methadone-dependent compared with control animals, but there was no significant difference in these values in female rats. Our results showed that methadone significantly reduced serum glucose as well as triglyceride levels only in male rats, this being associated with a reduction in the level of counterregulating hormones of carbohydrate metabolism. Changes in lipid profiles, however, occurred independently of gender. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.embargo 2021-11-26
dc.description.librarian am2021 en_ZA
dc.description.sponsorship The Vice Chancellor for the Research and Technology of the Birjand University of Medical Sciences. en_ZA
dc.description.uri https://www.springer.com/journal/43188 en_ZA
dc.identifier.citation Tahergorabi, Z., Rahmani, H., Williams, J. et al. The effect of methadone on blood glucose, lipids and glucose-modulating hormones in methadone-dependent Wistar rats. Toxicological Research 36, 221–226 (2020). https://doi.org/10.1007/s43188-019-00019-z. en_ZA
dc.identifier.issn 1976-8257 (print)
dc.identifier.issn 2234-2753 (online)
dc.identifier.other 10.1007/s43188-019-00019-z
dc.identifier.uri http://hdl.handle.net/2263/78896
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Korean Society of Toxicology 2019. The original publication is available at : https://www.springer.com/journal/43188. en_ZA
dc.subject Methadone en_ZA
dc.subject Glucose-modulating hormones en_ZA
dc.subject Wistar rats en_ZA
dc.subject Blood glucose en_ZA
dc.title The effect of methadone on blood glucose, lipids and glucose‑modulating hormones in methadone‑dependent Wistar rats en_ZA
dc.type Postprint Article en_ZA


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