The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

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dc.contributor.author Henning, Alischa
dc.contributor.author Clift, Sarah J.
dc.contributor.author Leisewitz, Andrew L.
dc.date.accessioned 2021-02-09T14:49:10Z
dc.date.issued 2020-05
dc.description.abstract To provide useful information based on the macropathology, histopathology and immunohistochemical investigation in the spleens of dogs with Babesia rossi infection. Control spleens were collected from four healthy dogs euthanized for welfare reasons. Nine dogs that died naturally because of a mono‐infection with Babesia rossi were selected for the diseased group. One haematoxylin‐and‐eosin–stained section of splenic tissue from each of the infected and control dogs was examined under the light microscope. Immunohistochemical markers were applied to characterize different immunocyte populations. The application of analytic software enabled semi‐quantitative comparison of leucocyte subpopulations. Routine splenic histopathology revealed diffuse intermingling of white and red pulp from infected dogs with a clear loss of distinction between these zones. Immunohistochemistry revealed an increase in the proportion of tissue resident and bone marrow origin macrophages in the infected spleens. Apart from a few remnant lymphocytes within the peri‐arteriolar lymphatic sheaths and follicles, the majority of the immunocytes redistributed to the red pulp, supporting the observation of white and red pulp intermingling. The majority of our findings are in agreement with histomorphological descriptions of the spleen in a variety of noncanid mammalian hosts with lethal malaria or babesiosis. en_ZA
dc.description.department Companion Animal Clinical Studies en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.embargo 2021-03-02
dc.description.librarian hj2021 en_ZA
dc.description.sponsorship The National Research Foundation en_ZA
dc.description.uri http://www.wileyonlinelibrary.com/journal/pim en_ZA
dc.identifier.citation Henning A., Clift S.J., Leisewitz A.L. The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi. Parasite Immunology 2020;42:e12706. https://doi.org/10.1111/pim.12706. en_ZA
dc.identifier.issn 0141-9838 (print)
dc.identifier.issn 1365-3024 (online)
dc.identifier.other 10.1111/pim.12706
dc.identifier.uri http://hdl.handle.net/2263/78335
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2020 John Wiley and Sons Ltd. This is the pre-peer reviewed version of the following article : The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi. Parasite Immunology 2020;42:e12706. https://doi.org/10.1111/pim.12706. The definite version is available at : http://www.wileyonlinelibrary.com/journal/pim. en_ZA
dc.subject Babesia rossi en_ZA
dc.subject Haemoprotozoa en_ZA
dc.subject Immunohistochemistry en_ZA
dc.subject Lymphocyte en_ZA
dc.subject Macrophage en_ZA
dc.subject Red pulp en_ZA
dc.subject White pulp en_ZA
dc.title The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi en_ZA
dc.type Postprint Article en_ZA


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