Adipogenesis : a complex interplay of multiple molecular determinants and pathways

Show simple item record Ambele, Melvin Anyasi Dhanraj, Priyanka Giles, Rachel Pepper, Michael Sean 2020-11-04T06:19:34Z 2020-11-04T06:19:34Z 2020-06-16
dc.description.abstract The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which migrate from the mesoderm to their anatomical localization. Most studies on adipocyte formation (adipogenesis) have used preadipocytes derived from adult stem/stromal cells. Adipogenesis consists of two phases, namely commitment and terminal di erentiation. This review discusses the role of signalling pathways, epigenetic modifiers, and transcription factors in preadipocyte commitment and di erentiation into mature adipocytes, as well as limitations in our understanding of these processes. To date, a limited number of transcription factors, genes and signalling pathways have been described to regulate preadipocyte commitment. One reason could be that most studies on adipogenesis have used preadipocytes already committed to the adipogenic lineage, which are therefore not suitable for studying preadipocyte commitment. Conversely, over a dozen molecular players including transcription factors, genes, signalling pathways, epigenetic regulators, and microRNAs have been described to be involved in the di erentiation of preadipocytes to adipocytes; however, only peroxisome proliferator-activated receptor gamma has proven to be clinically relevant. Adetailed understanding of how the molecular players underpinning adipogenesis relate to adipose tissue function could provide new therapeutic approaches for addressing obesity without compromising adipose tissue function. en_ZA
dc.description.department Immunology en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.librarian am2020 en_ZA
dc.description.sponsorship The South African Medical Research Council University Flagship Project, the SAMRC Extramural Unit for Stem Cell Research and Therapy, the Institute for Cellular and Molecular Medicine of the University of Pretoria, the South African National Research Foundation and National Health Laboratory Services. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Ambele, M.A., Dhanraj, P., Giles, R. et al. 2020, 'Adipogenesis : a complex interplay of multiple molecular determinants and pathways', International Journal of Molecular Sciences, vol. 21, art. 4283, pp. 1-27. en_ZA
dc.identifier.issn 1422-0067 (online)
dc.identifier.other 10.3390/ijms21124283
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2020 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. en_ZA
dc.subject Adipogenesis en_ZA
dc.subject Adipocyte commitment en_ZA
dc.subject Adipocyte progenitor en_ZA
dc.subject Transcription factor en_ZA
dc.subject Signalling pathway en_ZA
dc.subject Adipose tissue en_ZA
dc.subject Epigenetic regulator en_ZA
dc.subject MicroRNAs (miRNAs) en_ZA
dc.title Adipogenesis : a complex interplay of multiple molecular determinants and pathways en_ZA
dc.type Article en_ZA

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