A method for the in vitro study of drug transfer across ruminal epithelium
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Date
Authors
Jenkins, W.L.
Davis, L.E.
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS OpenJournals
Abstract
A simple method for the in vitro study of drug diffusion across ruminal epithelium is described. The characteristics of the
isolated membrane were defined by studies of ketone production from butyrate, histological studies, phenolsulphonthalein
penetration and permeability to pentobarbital, antipyrine and tetraethylammonium. The preparation was found to be
suitable for studies of less than 12 hours duration; after that time the integrity of the membrane as a barrier was lost due to
degenerative changes. The method had a primary advantage in that experimental variables could be rigorously controlled.
Description
This article is based as part of a dissertation submitted by the senior author' to the graduate Faculty of the University of Missouri in partial fulfillment of the requirements for the degree of Doctor of Philosophy.
Keywords
In vitro, Drug, Ruminal epithelium, Membrane
Sustainable Development Goals
Citation
Jenkins, W.L. & Davis, L.E. 1975, 'A method for the in vitro study of drug transfer across ruminal epithelium', Journal of the South African Veterinary Association, vol. 46, no. 2, pp. 153-160.