Bacterial vaginosis : current diagnostic avenues and future opportunities

Show simple item record Redelinghuys, Mathys J. Geldenhuys, Janri Jung, Hyun-Sul Kock, Marleen M. 2020-10-06T05:25:29Z 2020-10-06T05:25:29Z 2020-08-11
dc.description.abstract A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen peroxide producing bacteria, which provide protection against infections by maintaining a low pH. Changes in the bacterial compositions of the vaginal microbiome can lead to bacterial vaginosis (BV), which is often associated with vaginal inflammation. Bacterial vaginosis increases the risk of acquiring sexually transmitted infections (STIs) like human immunodeficiency virus (HIV) and affects women’s reproductive health negatively. In pregnant women, BV can lead to chorioamnionitis and adverse pregnancy outcomes, including preterm premature rupture of the membranes and preterm birth. In order to manage BV effectively, good diagnostic procedures are required. Traditionally clinical and microscopic methods have been used to diagnose BV; however, these methods require skilled staff and time and suffer from reduced sensitivity and specificity. New diagnostics, including highly sensitive and specific point-of-care (POC) tests, treatment modalities and vaccines can be developed based on the identification of biomarkers from the growing pool of vaginal microbiome and vaginal metabolome data. In this review the current and future diagnostic avenues will be discussed. en_ZA
dc.description.department Biochemistry en_ZA
dc.description.department Genetics en_ZA
dc.description.department Medical Microbiology en_ZA
dc.description.department Microbiology and Plant Pathology en_ZA
dc.description.librarian am2020 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Redelinghuys MJ, Geldenhuys J, Jung H and Kock MM (2020) Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities. Frontiers in Cellular and Infection Microbiology 10:354. doi: 10.3389/fcimb.2020.00354. en_ZA
dc.identifier.issn 2235-2988 (online)
dc.identifier.other 10.3389/fcimb.2020.00354
dc.language.iso en en_ZA
dc.publisher Frontiers Media en_ZA
dc.rights © 2020 Redelinghuys, Geldenhuys, Jung and Kock. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). en_ZA
dc.subject Bacterial vaginosis en_ZA
dc.subject Female genital tract en_ZA
dc.subject Diagnostics en_ZA
dc.subject Vaginal microbiome en_ZA
dc.subject Vaginal metabolome en_ZA
dc.subject Vaginal inflammation en_ZA
dc.subject Sexually transmitted infection (STI) en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.title Bacterial vaginosis : current diagnostic avenues and future opportunities en_ZA
dc.type Article en_ZA

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