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dc.contributor.author | Lall, Namrita![]() |
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dc.contributor.author | De Canha, Marco Nuno![]() |
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dc.contributor.author | Szuman, Karina![]() |
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dc.contributor.author | Charrouf, Zoubida![]() |
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dc.contributor.author | Davids, Lester M.![]() |
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dc.contributor.author | Rademan, Sunelle![]() |
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dc.date.accessioned | 2020-08-24T14:43:40Z | |
dc.date.available | 2020-08-24T14:43:40Z | |
dc.date.issued | 2019-01 | |
dc.description.abstract | INTRODUCTION: Argan oil is a well-known cosmeceutical that is commercially available. It is traditionally used for the treatment of acne and skin inflammation among others. The objective of this study was to assess the anti-proliferative and antibacterial activities of argan oil and a crude saponin extract from the argan tree (Argania spinosa (L.) Skeels) that is endemic to Morocco. MATERIALS AND METHODS: The anti-proliferative activity of argan oil and the crude saponin extract was assessed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay on A431; HaCat; HeLa; MCF-7 and UCT-Mel 1 cells. The antibacterial activity was evaluated by the broth microdilution method against two species of bacteria: Cutibacterium acnes and Prevotella intermedia. RESULTS: The results of this study indicated that the argan oil sample did not inhibit the cell growth of the specified cell lines up to 1000µg/ml, while the crude saponin extract had low anti-proliferative activity. The minimal inhibitory concentration (MIC) values for both the argan oil and the crude saponin extract were found to be 500µg/ml against Cutibacterium acnes. No antibacterial activity from the argan oil or the crude saponin extract was evident against Prevotella intermedia up to a concentration of 12.5mg/ml. CONCLUSION: The results of this study indicated that argan oil and the crude saponin extract might have direct inhibitory effects on the growth and proliferation of Cutibacterium acnes. This finding supports the use argan oil as a treatment for acne vulgaris. | en_ZA |
dc.description.department | Plant Production and Soil Science | en_ZA |
dc.description.librarian | pm2020 | en_ZA |
dc.description.sponsorship | National Research Foundation | en_ZA |
dc.description.uri | http://www.phcogfirst.com/content/pharmacognosy-journal | en_ZA |
dc.identifier.citation | Lall N, De Canha MN, Szuman K, Charrouf Z, Davids LM, Rademan S. The Anti-proliferative and Anti-bacterial Activity of Argan oil and Crude Saponin Extract from Argania spinosa (L.) Skeels. Pharmacognosy Journal 2019;11(1):26-31.. | en_ZA |
dc.identifier.issn | 0975-3575 (print) | |
dc.identifier.other | 10.5530/pj.2019.1.5 | |
dc.identifier.uri | http://hdl.handle.net/2263/75876 | |
dc.language.iso | en | en_ZA |
dc.publisher | Emanuscript Services | en_ZA |
dc.rights | © 2019 Phcog.Net. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License. | en_ZA |
dc.subject | Acne | en_ZA |
dc.subject | Broth microdilution method | en_ZA |
dc.subject | Prevotella intermedia | en_ZA |
dc.subject | Cutibacterium acnes | en_ZA |
dc.subject | XTT assay | en_ZA |
dc.title | The anti-proliferative and anti-bacterial activity of argan oil and crude saponin extract from Argania spinosa (L.) skeels | en_ZA |
dc.type | Article | en_ZA |