HIV and haematopoiesis

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dc.contributor.author Durandt, Chrisna
dc.contributor.author Potgieter, J.C.
dc.contributor.author Mellet, Juanita
dc.contributor.author Herd, Candice
dc.contributor.author Khoosal, R.
dc.contributor.author Nel, Jan Gert
dc.contributor.author Rossouw, Theresa M.
dc.contributor.author Pepper, Michael Sean
dc.date.accessioned 2020-05-27T09:51:58Z
dc.date.available 2020-05-27T09:51:58Z
dc.date.issued 2019-09
dc.description.abstract Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and neutropenia). Although there is a definite association between the severity of cytopenia and HIV disease stage, this relationship is not always linear. For example, cytopenias such as thrombocytopenia may occur during early stages of infection. The aetiology of these haematological abnormalities is complex and multifactorial, including druginduced impaired haematopoiesis, bone marrow suppression due to infiltration of infectious agents or malignant cells, HIV-induced impaired haematopoiesis, and several other factors. In this review, we describe the frequencies of anaemia, thrombocytopenia and neutropenia reported for HIV-infected, treatment-naïve cohorts studied in eastern and southern sub-Saharan African countries. We present a rational approach for the use of diagnostic tests during the workup of HIV-infected patients presenting with cytopenia, and discuss how HIV impacts on haematopoietic stem/progenitor cells (HSPCs) resulting in impaired haematopoiesis. Finally, we describe the direct and indirect effects of HIV on HSPCs which result in defective haematopoiesis leading to cytopenias. en_ZA
dc.description.department Haematology en_ZA
dc.description.department Immunology en_ZA
dc.description.librarian pm2020 en_ZA
dc.description.uri http://www.samj.org.za en_ZA
dc.identifier.citation Durandt, C., Potgieter, J.C., Mellet, J., Herd, C., Khoosal, R., Nel, J.G., Rossouw, T. & Pepper, M.S. 2019, 'HIV and haematopoiesis', South African Medical Journal, vol. 109, no. 8, pp. S41-S46. " en_ZA
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.other 10.7196/SAMJ.2019.v109i8b.13829
dc.identifier.uri http://hdl.handle.net/2263/74751
dc.language.iso en en_ZA
dc.publisher Health and Medical Publishing Group en_ZA
dc.rights © 2019, South African Medical Association. This article is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Haematopoiesis en_ZA
dc.title HIV and haematopoiesis en_ZA
dc.type Article en_ZA


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