Family history identifies sporadic schizoaffective disorder as a subtype for genetic studies

Show simple item record Van der Merwe, Nicolaas J. Karayiorgou, Maria Ehlers, Rene Roos, J.L. (Johannes Louw) 2020-05-06T11:14:46Z 2020-05-06T11:14:46Z 2020-04
dc.description.abstract BACKGROUND : Schizophrenia is a heterogeneous disorder with strong genetic vulnerability. Family history of schizophrenia has been considered in genetic studies under several models. De novo genetic events seem to play a larger role in sporadic cases. AIM : This study used the familial–sporadic distinction with the aim of identifying a more homogeneous phenotype to delineate the genetic and clinical complexity of schizophrenia. SETTING : The study was conducted at Weskoppies Hospital, Pretoria, South Africa. METHODS : The study included 384 participants with schizophrenia or schizoaffective disorder from the Afrikaner founder population in South Africa who are considered comparable to Caucasian patients from the United States. A comprehensive data capturing sheet was completed. RESULTS : When schizophrenia and schizoaffective disorder diagnoses were considered jointly, we found no significant differences between the sporadic and the familial groups for age at disease onset, season of birth, comorbid diagnoses, clinical symptomatology, history of suicide or marital status. When the diagnoses were examined separately, however, the sporadic schizoaffective disorder, bipolar type, was found to have a significantly lower age at onset (mean 20.6 vs. 25.3 years). CONCLUSION : The sporadic schizoaffective disorder, bipolar type, forms a more homogeneous subgroup for genetic studies. en_ZA
dc.description.department Psychiatry en_ZA
dc.description.department Statistics en_ZA
dc.description.librarian hj2020 en_ZA
dc.description.sponsorship The National Institute for Mental Health (grant number R01MH61399 to M.K.) and the National Research Foundation (grant number IFR160224159056 to J.L.R). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Van der Merwe NJ, Karayiorgou M, Ehlers R, Roos JL. Family history identifies sporadic schizoaffective disorder as a subtype for genetic studies. South African Journal of Psychiatry 2020;26(0), a1393. en_ZA
dc.identifier.issn 1608-9685 (print)
dc.identifier.issn 2078-6786 (online)
dc.identifier.other 10.4102/sajpsychiatry.v26i0.1393
dc.language.iso en en_ZA
dc.publisher AOSIS Open Journals en_ZA
dc.rights © 2020. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. en_ZA
dc.subject Schizophrenia en_ZA
dc.subject Family history en_ZA
dc.subject Genetic studies en_ZA
dc.subject Novo genetic events en_ZA
dc.subject Familial-sporadic distinction en_ZA
dc.title Family history identifies sporadic schizoaffective disorder as a subtype for genetic studies en_ZA
dc.type Article en_ZA

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