This article begins with a few thoughts and some historical and canonical encounters about how lay and ordained people with disabilities have been involved in Orthodox mission work in the past. It then presents two concrete contemporary situations in which people with disabilities are involved in Orthodox ordained ministry work despite the persisting tradition that disabled people not be ordained. The first example is taken from the Eritrean Orthodox Tewahedo Church, where the involvement of people with disabilities in both ordained and lay ministry provides significant support for a church that lives in a delicate situation. The second example is taken from the Romanian Orthodox Church and presents the case of Father Theophilus Părăian, one of the most prominent contemporary Romanian Orthodox monastic figures, who served as an ordained priest despite his disability. This article pleads for a deeper involvement of disabled people in both ordained and lay ministry in Orthodox churches.