An African origin for the intimate association between humans and Helicobacter pylori

Show simple item record Linz, Bodo Balloux, Francois Moodley, Yoshan Manica, Andrea Liu, Hua Roumagnac, Philippe Falush, Daniel Stamer, Christiana Prugnolle, Franck Van der Merwe, Schalk Willem Yamaoka, Yoshio Graham, David Y. Perez-Trallero, Emilio Wadstrom, Torkel Suerbaum, Sebastian Achtman, Mark 2008-09-23T07:24:57Z 2008-09-23T07:24:57Z 2007-02
dc.description.abstract Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation the age of an association between these bacteria with humans remains highly controversial. Here we show, using sequences from a large data set of bacterial strains that, as in humans, genetic diversity in H. pylori decreases with geographic distance from east Africa, the cradle of modern humans. We also observe similar clines of genetic isolation by distance (IBD) for both H. pylori and its human host at a worldwide scale. Like humans, simulations indicate that H. pylori seems to have spread from east Africa around 58,000 yr ago. Even at more restricted geographic scales, where IBD tends to become blurred, principal component clines in H. pylori from Europe strongly resemble the classical clines for Europeans described by Cavalli-Sforza and colleagues7. Taken together, our results establish that anatomically modern humans were already infected by H. pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since. en
dc.identifier.citation Linz, B, Balloux, F, Moodley, Y, Manica, A, Liu, H, Roumagnac, P, Falush, D, Stamer, C, Prugnolle, F, Van der Merwe, SW, Yamaoka, Y, Graham, DY, Perez-Trallero, E, Wadstrom, T, Suerbaum, S & Achtman, M 2007, 'An African origin for the intimate association between humans and Helicobacter pylori', Nature, vol. 445, no. 7130, pp. 915-918, [] en
dc.identifier.issn 0028-0836
dc.identifier.other 10.1038/nature05562
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.rights Nature Publishing Group en
dc.subject African en
dc.subject Helicobacter pylori en
dc.subject Origin en
dc.subject Humans en
dc.subject Stomach infections en
dc.subject Human association en
dc.subject Phylogeographic differentiation en
dc.subject Bacterial strains en
dc.subject Genetic diversity en
dc.subject Geographic distances en
dc.subject East Africa en
dc.subject Genetic isolation en
dc.subject Human host en
dc.subject Geographic scales en
dc.subject Spreading en
dc.subject Modern humans en
dc.subject Europe en
dc.subject Infection en
dc.subject Human populations en
dc.subject Genetic patterns en
dc.subject Ancestral populations en
dc.subject Geographic patterns en
dc.subject Hypothetical scenarios en
dc.subject Bacterial isolations en
dc.subject Sequencing en
dc.subject Transmission en
dc.subject.lcsh Helicobacter pylori
dc.subject.lcsh Stomach--Infections
dc.subject.lcsh Africa, East
dc.subject.lcsh Human beings
dc.title An African origin for the intimate association between humans and Helicobacter pylori en
dc.type Postprint Article en

Files in this item

This item appears in the following Collection(s)

Show simple item record