dc.contributor.author |
Cohen, Cheryl
|
|
dc.contributor.author |
Tshangela, Akhona
|
|
dc.contributor.author |
Valley-Omar, Ziyaad
|
|
dc.contributor.author |
Iyengar, Preetha
|
|
dc.contributor.author |
Von Mollendorf, Claire
|
|
dc.contributor.author |
Walaza, Sibongile
|
|
dc.contributor.author |
Hellferscee, Orienka
|
|
dc.contributor.author |
Venter, Marietjie
|
|
dc.contributor.author |
Martinson, Neil
|
|
dc.contributor.author |
Mahlase, Gethwana
|
|
dc.contributor.author |
McMorrow, Meredith L.
|
|
dc.contributor.author |
Cowling, Benjamin J.
|
|
dc.contributor.author |
Treurnicht, Florette K.
|
|
dc.contributor.author |
Cohen, Adam L.
|
|
dc.contributor.author |
Tempia, Stefano
|
|
dc.date.accessioned |
2019-12-06T08:45:41Z |
|
dc.date.issued |
2019-05 |
|
dc.description.abstract |
BACKGROUND : We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases. METHODS : Index cases were the first symptomatic person in a household with influenza-like illness, testing influenza positive on real-time reverse transcription polymerase chain reaction (rRT-PCR). Nasopharyngeal swabs collected from household contacts every 4 days were tested by rRT-PCR. Factors associated with SIR were evaluated using logistic regression. RESULTS : We enrolled 28 HIV-infected and 57 HIV-uninfected index cases. On multivariable analysis, HIV-infected index cases were less likely to transmit influenza to household contacts (odds ratio [OR] 0.2; 95% confidence interval [CI], 0.1–0.6; SIR 16%, 18/113 vs 27%, 59/220). Factors associated with increased SIR included index age group 1–4 years (OR 3.6; 95% CI, 1.2–11.3) and 25–44 years (OR 8.0; 95% CI, 1.8–36.7), and contact age group 1–4 years (OR 3.5; 95% CI, 1.2–10.3) compared to 5–14 years, and sleeping with index case (OR 2.7; 95% CI, 1.3–5.5). HIV infection of index case was not associated with SI. CONCLUSIONS : HIV-infection was not associated with SI. Increased infectiousness of HIV-infected individuals is likely not an important driver of community influenza transmission. |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.embargo |
2020-05-15 |
|
dc.description.librarian |
hj2019 |
en_ZA |
dc.description.sponsorship |
The National Institute for Communicable Diseases of the National Health Laboratory Service and the US Centers for Disease Control and Prevention [co-operative agreement number: 5U51IP000155. |
en_ZA |
dc.description.uri |
https://academic.oup.com/jid |
en_ZA |
dc.identifier.citation |
Cohen, C., Tshangela, A., Valley-Omar, Z. et al. Household transmission of seasonal influenza from HIV-infected and HIV-uninfected individuals in South Africa, 2013-2014. The Journal of Infectious Diseases, Volume 219, Issue 10, 15 May 2019, Pages 1605–1615, https://doi.org/10.1093/infdis/jiy702.
. |
en_ZA |
dc.identifier.issn |
0022-1899 (print) |
|
dc.identifier.issn |
1537-6613 (online) |
|
dc.identifier.other |
10.1093/infdis/jiy702 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/72534 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Oxford University Press |
en_ZA |
dc.rights |
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version is : 'Household transmission of seasonal influenza from HIV-infected and HIV-uninfected individuals in South Africa, 2013-2014', Journal of Infectious Diseases, vol. 219, no. 10. pp. 1605-1615, 2019. doi : , is available online at : https://academic.oup.com/jid. |
en_ZA |
dc.subject |
Influenza |
en_ZA |
dc.subject |
Household |
en_ZA |
dc.subject |
Transmission |
en_ZA |
dc.subject |
Human immunodeficiency virus (HIV) |
en_ZA |
dc.subject |
South Africa (SA) |
en_ZA |
dc.subject |
Polymerase chain reaction (PCR) |
en_ZA |
dc.subject |
HIV infection |
en_ZA |
dc.subject |
Secondary infection risk (SIR) |
en_ZA |
dc.subject |
Reverse transcription polymerase chain reaction (rRT-PCR) |
en_ZA |
dc.title |
Household transmission of seasonal influenza from HIV-infected and HIV-uninfected individuals in South Africa, 2013-2014 |
en_ZA |
dc.type |
Postprint Article |
en_ZA |