Abstract:
We recently reported a novel hybrid batch–flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl
group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction
of aldehydes. The method developed affords yields which are comparable to those under batch conditions, has a reduced reaction
time and improved space-time productivity. Furthermore, the approach allows the selective reduction of aldehydes in the presence
of ketones and has been demonstrated as a continuous process.
