dc.contributor.author |
Sathekge, Mike Machaba
|
|
dc.contributor.author |
Garcia‑Perez, Osvaldo
|
|
dc.contributor.author |
Paez, Diana
|
|
dc.contributor.author |
El‑Haj, Noura
|
|
dc.contributor.author |
Kain‑Godoy, Taylor
|
|
dc.contributor.author |
Lawal, Ismaheel Opeyemi
|
|
dc.contributor.author |
Estrada‑Lobato, Enrique
|
|
dc.date.accessioned |
2019-10-31T11:32:30Z |
|
dc.date.available |
2019-10-31T11:32:30Z |
|
dc.date.issued |
2018-01 |
|
dc.description.abstract |
OBJECTIVE : To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal
infection using 99mTc-UBI 29-4.
MATERIALS AND METHODS : 184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging
with 99mTc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent
analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology
or clinical follow-up.
RESULTS : 99mTc-UBI 29-41 was true positive in 105/184 patients and true negative in 65/184 patients. When differentiating
between soft tissue and bone infection, planar + SPECT-only imaging had a sensitivity, specificity, positive predictive value,
negative predictive value and accuracy of 95.0, 74.3, 84.8, 91.3 and 86.9%, respectively, versus 99.0, 94.5, 92.5, 98.5 and
94.5% for SPECT/CT. SPECT/CT resulted in a change in reviewers’ confidence in the final diagnosis in 91/184 patients.
Inter-observer agreement was better with SPECT/CT compared with planar + SPECT imaging (kappa 0.87, 95% CI 0.71–0.85
versus kappa 0.81, 95% CI 0.58–0.75).
CONCLUSION : Addition of CT to planar and SPECT-only imaging led to an increase in diagnostic performance and an improvement
in reviewers’ confidence and inter-observer agreement in differentiating bone from soft tissue infection. |
en_ZA |
dc.description.department |
Nuclear Medicine |
en_ZA |
dc.description.librarian |
am2019 |
en_ZA |
dc.description.uri |
http://link.springer.com/journal/12149 |
en_ZA |
dc.identifier.citation |
Sathekge, M., Garcia-Perez, O., Paez, D. et al. Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT. Annals of Nuclear Medicine (2018) 32: 54-59. https://doi.org/10.1007/s12149-017-1219-7. |
en_ZA |
dc.identifier.issn |
0914-7187 (print) |
|
dc.identifier.issn |
1864-6433 (online) |
|
dc.identifier.other |
10.1007/s12149-017-1219-7 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/72081 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Springer |
en_ZA |
dc.rights |
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
en_ZA |
dc.subject |
99mTc-UBI 29-41 |
en_ZA |
dc.subject |
SPECT/CT |
en_ZA |
dc.subject |
Infection |
en_ZA |
dc.subject |
Musculoskeletal |
en_ZA |
dc.title |
Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT |
en_ZA |
dc.type |
Article |
en_ZA |