Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT

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dc.contributor.author Sathekge, Mike Machaba
dc.contributor.author Garcia‑Perez, Osvaldo
dc.contributor.author Paez, Diana
dc.contributor.author El‑Haj, Noura
dc.contributor.author Kain‑Godoy, Taylor
dc.contributor.author Lawal, Ismaheel
dc.contributor.author Estrada‑Lobato, Enrique
dc.date.accessioned 2019-10-31T11:32:30Z
dc.date.available 2019-10-31T11:32:30Z
dc.date.issued 2018-01
dc.description.abstract OBJECTIVE : To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using 99mTc-UBI 29-4. MATERIALS AND METHODS : 184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging with 99mTc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology or clinical follow-up. RESULTS : 99mTc-UBI 29-41 was true positive in 105/184 patients and true negative in 65/184 patients. When differentiating between soft tissue and bone infection, planar + SPECT-only imaging had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 95.0, 74.3, 84.8, 91.3 and 86.9%, respectively, versus 99.0, 94.5, 92.5, 98.5 and 94.5% for SPECT/CT. SPECT/CT resulted in a change in reviewers’ confidence in the final diagnosis in 91/184 patients. Inter-observer agreement was better with SPECT/CT compared with planar + SPECT imaging (kappa 0.87, 95% CI 0.71–0.85 versus kappa 0.81, 95% CI 0.58–0.75). CONCLUSION : Addition of CT to planar and SPECT-only imaging led to an increase in diagnostic performance and an improvement in reviewers’ confidence and inter-observer agreement in differentiating bone from soft tissue infection. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.librarian am2019 en_ZA
dc.description.uri http://link.springer.com/journal/12149 en_ZA
dc.identifier.citation Sathekge, M., Garcia-Perez, O., Paez, D. et al. Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT. Annals of Nuclear Medicine (2018) 32: 54-59. https://doi.org/10.1007/s12149-017-1219-7. en_ZA
dc.identifier.issn 0914-7187 (print)
dc.identifier.issn 1864-6433 (online)
dc.identifier.other 10.1007/s12149-017-1219-7
dc.identifier.uri http://hdl.handle.net/2263/72081
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). en_ZA
dc.subject 99mTc-UBI 29-41 en_ZA
dc.subject SPECT/CT en_ZA
dc.subject Infection en_ZA
dc.subject Musculoskeletal en_ZA
dc.title Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT en_ZA
dc.type Article en_ZA


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