Chemical equilibrium at the tick-host feeding interface : a critical examination of biological relevance in hematophagous behavior

Show simple item record Mans, Ben J. (Barend Johannes) 2019-08-21T09:34:00Z 2019-08-21T09:34:00Z 2019-05-01
dc.description.abstract Ticks secrete hundreds to thousands of proteins into the feeding site, that presumably all play important functions in the modulation of host defense mechanisms. The current review considers the assumption that tick proteins have functional relevance during feeding. The feeding site may be described as a closed system and could be treated as an ideal equilibrium system, thereby allowing modeling of tick–host interactions in an equilibrium state. In this equilibrium state, the concentration of host and tick proteins and their affinities will determine functional relevance at the tick–host interface. Using this approach, many characterized tick proteins may have functional relevant concentrations and affinities at the feeding site. Conversely, the feeding site is not an ideal closed system, but is dynamic and changing, leading to possible overestimation of tick protein concentration at the feeding site and consequently an overestimation of functional relevance. Ticks have evolved different possible strategies to deal with this dynamic environment and overcome the barrier that equilibrium kinetics poses to tick feeding. Even so, cognisance of the limitations that equilibrium binding place on deductions of functional relevance should serve as an important incentive to determine both the concentration and affinity of tick proteins proposed to be functional at the feeding site. en_ZA
dc.description.department Veterinary Tropical Diseases en_ZA
dc.description.librarian am2019 en_ZA
dc.description.sponsorship The Economic Competitive Support Programme (30/01/V010), the National Research Foundation (NRF) Incentive Funding (IFR2011032400016) for Rated Researchers (NRF-Mans), and the National Research Foundation (NRF) Competitive Funding for Rated Researchers (CPRR180101296400). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Mans BJ (2019) Chemical Equilibrium at the Tick–Host Feeding Interface: A Critical Examination of Biological Relevance in Hematophagous Behavior. Frontiers in Physiology 10:530. DOI: 10.3389/fphys.2019.00530. en_ZA
dc.identifier.issn 1664-042X (online)
dc.identifier.other 10.3389/fphys.2019.00530
dc.language.iso en en_ZA
dc.publisher Frontiers Media en_ZA
dc.rights © 2019 Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). en_ZA
dc.subject Tick en_ZA
dc.subject Host en_ZA
dc.subject Feeding en_ZA
dc.subject Affinity en_ZA
dc.subject Equilibrium en_ZA
dc.subject Function en_ZA
dc.subject Relevance en_ZA
dc.title Chemical equilibrium at the tick-host feeding interface : a critical examination of biological relevance in hematophagous behavior en_ZA
dc.type Article en_ZA

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