Prevalence of Mycobacterium bovis infection in traditionally managed cattle at the wildlife-livestock interface in South Africa in the absence of control measures

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dc.contributor.author Sichewo, Petronillah Rudo
dc.contributor.author Etter, Eric Marcel Charles
dc.contributor.author Michel, Anita Luise
dc.date.accessioned 2019-08-15T09:28:25Z
dc.date.issued 2019-08
dc.description.abstract Cattle are the domestic animal reservoir for Mycobacterium bovis (M. bovis) which also affects other domestic animals, several wildlife species and humans leading to tuberculosis. The study area is in a resource-poor community that is surrounded by several game parks, where M. bovis infection has been previously diagnosed in wildlife. A cross-sectional study was carried out to determine the prevalence of M. bovis infection in 659 cattle from a total of 192 traditionally managed herds using the BOVIGAM® interferon gamma assay (IFN-γ). Infection was confirmed by post mortem examination and M. bovis isolation from three test-positive cattle. Genotyping of the M. bovis isolates was done using spoligotyping and VNTR (variable number of tandem repeats typing). The apparent M. bovis prevalence rate in cattle at animal level was 12% with a true population prevalence of 6% (95% Confidence interval (C.I) 3.8 to 8.1) and a herd prevalence of 28%. Spoligotyping analysis revealed that the M. bovis isolates belonged to spoligotype SB0130 and were shared with wildlife. Three VNTR profiles were identified among the SB0130 isolates from cattle, two of which had previously been detected in buffalo in a game reserve adjacent to the study area. The apparent widespread presence of M. bovis in the cattle population raises a serious public health concern and justifies further investigation into the risk factors for M. bovis transmission to cattle and humans. Moreover, there is an urgent need for effective bTB control measures to reduce infection in the communal cattle and prevent its spread to uninfected herds. en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.department Veterinary Tropical Diseases en_ZA
dc.description.embargo 2020-08-01
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship Partially supported by the Grant or Cooperative Agreement Number, [5 NU2GGH001874–02-00], funded by the Centers for Disease Control and Prevention. en_ZA
dc.description.uri http://link.springer.com/journal/11259 en_ZA
dc.identifier.citation Sichewo, P.R., Etter, E.M.C. & Michel, A.L. Prevalence of Mycobacterium bovis infection in traditionally managed cattle at the wildlife-livestock interface in South Africa in the absence of control measures. Veterinary Research Communications (2019) 43: 155-164. https://doi.org/10.1007/s11259-019-09756-w. en_ZA
dc.identifier.issn 0165-7380 (print)
dc.identifier.issn 1573-7446 (online)
dc.identifier.other 10.1007/s11259-019-09756-w
dc.identifier.uri http://hdl.handle.net/2263/71101
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Springer Nature B.V. 2019. The original publication is available at http://link.springer.comjournal/11259. en_ZA
dc.subject Bovine tuberculosis (bTB) en_ZA
dc.subject Cattle en_ZA
dc.subject Mycobacterium bovis en_ZA
dc.subject Wildlife-livestock interface en_ZA
dc.title Prevalence of Mycobacterium bovis infection in traditionally managed cattle at the wildlife-livestock interface in South Africa in the absence of control measures en_ZA
dc.type Postprint Article en_ZA


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