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dc.contributor.author | Eigenbrod, Ole![]() |
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dc.contributor.author | Debus, Karlien Y.![]() |
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dc.contributor.author | Reznick, Jane![]() |
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dc.contributor.author | Bennett, Nigel Charles![]() |
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dc.contributor.author | Sanchez-Carranza, Oscar![]() |
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dc.contributor.author | Omerbasic, Damir![]() |
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dc.contributor.author | Hart, Daniel William![]() |
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dc.contributor.author | Barker, Alison J.![]() |
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dc.contributor.author | Zhong, Wei![]() |
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dc.contributor.author | Lutermann, Heike![]() |
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dc.contributor.author | Katandukila, Jestina V.![]() |
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dc.contributor.author | Mgode, Georgies Frank![]() |
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dc.contributor.author | Park, Thomas J.![]() |
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dc.contributor.author | Lewin, Gary R.![]() |
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dc.date.accessioned | 2019-07-17T12:52:52Z | |
dc.date.available | 2019-07-17T12:52:52Z | |
dc.date.issued | 2019-05 | |
dc.description.abstract | Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Nav1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors. These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant. Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain. | en_ZA |
dc.description.department | Mammal Research Institute | en_ZA |
dc.description.department | Zoology and Entomology | en_ZA |
dc.description.librarian | hj2019 | en_ZA |
dc.description.sponsorship | Grants from the European Research Council (advanced grant 294678 to G.R.L.) and the Deutsche Forschungsgemeinschaft SFB 958 (to G.R.L.), by a South African Research Chair for Mammalian Behavioural Ecology and Physiology to N.C.B., and by a National Science Foundation grant to T.J.P. | en_ZA |
dc.description.uri | http://www.sciencemag.org | en_ZA |
dc.identifier.citation | Eigenbrod, O., Debus, K.Y., Reznick, J. et al. 2019, 'Rapid molecular evolution of pain insensitivity in multiple African rodents', Science, vol, 364, no. 6443, pp. 852-859. | en_ZA |
dc.identifier.issn | 0036-8075 (print) | |
dc.identifier.issn | 1095-9203 (online) | |
dc.identifier.other | 10.1126/science.aau0236 | |
dc.identifier.uri | http://hdl.handle.net/2263/70756 | |
dc.language.iso | en | en_ZA |
dc.publisher | American Association for the Advancement of Science | en_ZA |
dc.rights | © 2019 American Association for the Advancement of Science. All Rights Reserved. | en_ZA |
dc.subject | Heterocephalus glaber | en_ZA |
dc.subject | Hexapoda | en_ZA |
dc.subject | Rattus | en_ZA |
dc.subject | Rodentia | en_ZA |
dc.subject | Algogens | en_ZA |
dc.subject | Allyl isothiocyanate (AITC) | en_ZA |
dc.subject | African rodents | en_ZA |
dc.subject | Pain insensitivity | en_ZA |
dc.title | Rapid molecular evolution of pain insensitivity in multiple African rodents | en_ZA |
dc.type | Postprint Article | en_ZA |