Association between gestational diabetes and biomarkers : a role in diagnosis

Show simple item record

dc.contributor.author Adam, Sumaiya
dc.contributor.author Pheiffer, Carmen
dc.contributor.author Dias, Stephanie
dc.contributor.author Rheeder, Paul
dc.date.accessioned 2019-04-05T05:17:21Z
dc.date.available 2019-04-05T05:17:21Z
dc.date.issued 2018
dc.description.abstract BACKGROUND : We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. METHODS : In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. RESULTS : Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier (p = 0.04) and had more clinical risk factors (p = 0.008). We found a significant difference in fasting insulin (p < 0.001), adiponectin (p = 0.046), HOMA (p < 0.001) and QUICKI (p < 0.001). HOMA (AUROC = 0.82) or QUICKI (AUROC = 0.82) improved the ability of risk factors to identify women at high risk of GDM. CONCLUSIONS : Insulin sensitivity markers are promising tools to identify women at high risk of GDM. en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship The Society for Endocrinology, Metabolism and Diabetes of South Africa (SEMDSA), South African Sugar Association (SASA), and Roche Pharmaceuticals. en_ZA
dc.description.uri http://www.tandfonline.com/loi/ibmk20 en_ZA
dc.identifier.citation Adam, S., Pheiffer, C., Dias, S. et al. 2018, 'Association between gestational diabetes and biomarkers : a role in diagnosis', Biomarkers, vol. 23, no. 4, pp. 386-391. en_ZA
dc.identifier.issn 1354-750X (print)
dc.identifier.issn 1366-5804 (online)
dc.identifier.other 10.1080/1354750X.2018.1432690
dc.identifier.uri http://hdl.handle.net/2263/68921
dc.language.iso en en_ZA
dc.publisher Taylor and Francis en_ZA
dc.rights © 2018 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Biomarkers, vol. 23, no. 4, pp. 386-391, 2018. doi : 10.1080/1354750X.2018.1432690. Biomarkers is available online at : http://www.tandfonline.com/loi/ibmk20. en_ZA
dc.subject Protein en_ZA
dc.subject Pregnancy en_ZA
dc.subject Adiponectin en_ZA
dc.subject Women en_ZA
dc.subject Type 2 diabetes mellitus (T2DM) en_ZA
dc.subject Insulin sensitivity en_ZA
dc.subject Biomarkers en_ZA
dc.subject Gestational diabetes (GDM) en_ZA
dc.title Association between gestational diabetes and biomarkers : a role in diagnosis en_ZA
dc.type Postprint Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record