Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa

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dc.contributor.author Qekwana, Daniel Nenene
dc.contributor.author Phophi, Lufuno
dc.contributor.author Naidoo, Vinny
dc.contributor.author Oguttu, James Wabwire
dc.contributor.author Odoi, Agricola
dc.date.accessioned 2019-03-06T13:00:50Z
dc.date.available 2019-03-06T13:00:50Z
dc.date.issued 2018-07-31
dc.description.abstract BACKGROUND : This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012. METHODS : The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR). RESULTS : A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004) decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug resistance (PDR), respectively. CONCLUSIONS : Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting prognosis of UTI treatments. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian am2019 en_ZA
dc.description.uri https://bmcvetres.biomedcentral.com en_ZA
dc.identifier.citation Qekwana, D.N., Phophi, L., Naidoo, V. et al. 2018, 'Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa', BMC Veterinary Research, vol. 14, art. 228, pp. 1-6. en_ZA
dc.identifier.issn 1746-6148 (online)
dc.identifier.other 10.1186/s12917-018-1552-7
dc.identifier.uri http://hdl.handle.net/2263/68593
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © The Author(s). 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). en_ZA
dc.subject Urinary tract infection (UTI) en_ZA
dc.subject Canine en_ZA
dc.subject Multidrug resistance en_ZA
dc.subject Extensive drug resistance en_ZA
dc.subject Pan-drug resistance en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject Teaching hospital en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Dogs en_ZA
dc.subject Escherichia coli en_ZA
dc.subject Cochran Armitage trend test en_ZA
dc.subject Bacterium isolation en_ZA
dc.subject Bacterium identification en_ZA
dc.subject Bacterial load en_ZA
dc.subject Antibiotic resistance en_ZA
dc.subject Animal tissue en_ZA
dc.subject Tylosin en_ZA
dc.subject Penicillin G en_ZA
dc.subject Orbifloxacin en_ZA
dc.subject Enrofloxacin en_ZA
dc.subject Clindamycin en_ZA
dc.subject Cefalotin en_ZA
dc.subject Antimicrobial resistance (AMR) en_ZA
dc.title Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa en_ZA
dc.type Article en_ZA


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