BACKGROUND : This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and
antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007–2012.
METHODS : The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models
were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR).
RESULTS : A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004)
decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were
high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels
of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug
resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug
resistance (PDR), respectively.
CONCLUSIONS : Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high
levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting
prognosis of UTI treatments.
Ismail, Nazir Ahmed; Mvusi, Lindiwe; Nanoo, Ananta; Dreyer, Andries; Omar, Shaheed V.; Babatunde, Sanni; Molebatsi, Thabo; Van der Walt, Martie; Adelekan, Adeboye; Deyde, Varough; Ihekweazu, Chikwe; Madhi, S.A.(Elsevier, 2018-07)
BACKGROUND : Globally, per-capita, South Africa reports a disproportionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the ...
Raman, Jaishree; Kagoro, Frank M.; Mabuza, Aaron; Malatje, Gillian; Reid, Anthony; Barnes, Karen I.(BioMed Central, 2019-08-22)
BACKGROUND : The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials
threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring ...
Mmatli, Masego; Mbelle, Nontombi Marylucy; Maningi, Nontuthuko Excellent; Osei Sekyere, John(American Society for Microbiology, 2020-11)
The spread of carbapenem- and polymyxin-resistant Enterobacteriaceae poses a significant threat to public health, challenging clinicians worldwide with limited therapeutic options. This review describes the current coding ...