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dc.contributor.author | Mc Fie, Sarah![]() |
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dc.contributor.author | Abrahams, Shameemah![]() |
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dc.contributor.author | Patricios, Jonathan Speridon![]() |
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dc.contributor.author | Suter, Jason![]() |
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dc.contributor.author | Posthumus, Michael![]() |
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dc.contributor.author | September, Alison V.![]() |
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dc.date.accessioned | 2019-03-04T09:47:32Z | |
dc.date.issued | 2018 | |
dc.description.abstract | The objective was to investigate the relationship between IL-1B rs16944, IL-6 rs1800795, and CASP8 rs3834129 genetic polymorphisms and concussion severity. Rugby players from high school, senior amateur, and professional teams completed a concussion severity questionnaire and donated a DNA sample. Participants (n = 163) were split into symptom severity groups around the median number and duration of symptoms. The frequency of participants with high symptom counts (more than five symptoms) increased across the IL-1B (C/C: 35%; C/T: 51%; T/T: 56%; P = 0.047) and the IL-6 (C/C: 31%; C/G: 44%; G/G: 58%; P = 0.027) genotypes. The C–C inferred interleukin allele construct frequency, created from combining the IL-1B and IL-6 genotype data, was lower in participants reporting a high symptom count (18%), compared to those with a low symptom count (fewer than six symptoms, 36%, P = 0.002). Similarly, the C–C inferred interleukin allele construct frequency was lower in those reporting prolonged symptom duration (more than one week, 16%), as opposed to short symptom duration (less than one week, 34%, P = 0.015). This study provides evidence of novel inflammatory pathway genetic associations with concussion severity, which supports the hypothesis implicating neuroinflammation in the development of concussion symptoms. | en_ZA |
dc.description.department | Sports Medicine | en_ZA |
dc.description.embargo | 2019-03-06 | |
dc.description.librarian | hj2019 | en_ZA |
dc.description.sponsorship | The National Research Foundation funded the study (A.V.S., grant number 90942), (M.P., grant numbers 93416:2015, 85534:2015). The National Research Foundation and the University of Cape Town funded S.A. and S.M. | en_ZA |
dc.description.uri | https://www.tandfonline.com/loi/rjsp20 | en_ZA |
dc.identifier.citation | Sarah Mc Fie, Shameemah Abrahams, Jon Patricios, Jason Suter, MichaelPosthumus & Alison V. September (2018) Inflammatory and apoptotic signalling pathways andconcussion severity: a genetic association study, Journal of Sports Sciences, 36:19, 2226-2234,DOI: 10.1080/02640414.2018.1448570. | en_ZA |
dc.identifier.issn | 0264-0414 (print) | |
dc.identifier.issn | 1466-447X (online) | |
dc.identifier.other | 10.1080/02640414.2018.1448570 | |
dc.identifier.uri | http://hdl.handle.net/2263/68546 | |
dc.language.iso | en | en_ZA |
dc.publisher | Routledge | en_ZA |
dc.rights | © 2018 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Journal of Sports Sciences, vol. 36, no. 19, pp. 2226-2234, 2018. doi : 10.1080/02640414.2018.1448570. Journal of Sports Sciences is available online at : http://www.tandfonline.comloi/rjsp20. | en_ZA |
dc.subject | Concussion | en_ZA |
dc.subject | Genetics | en_ZA |
dc.subject | Interleukin | en_ZA |
dc.subject | Neuroinflammation | en_ZA |
dc.subject | Rugby | en_ZA |
dc.subject | Traumatic brain injury (TBI) | en_ZA |
dc.subject | Interleukin-1 receptor antagonist | en_ZA |
dc.subject | White-matter integrity | en_ZA |
dc.subject | Focal cerebral-ischemia | en_ZA |
dc.subject | Apoe epsilon-4 allele | en_ZA |
dc.subject | Necrosis-factor-alpha | en_ZA |
dc.subject | Neuronal injury | en_ZA |
dc.subject | Nervous system | en_ZA |
dc.subject | Nitric oxide (NO) | en_ZA |
dc.subject | Risk factors | en_ZA |
dc.title | Inflammatory and apoptotic signalling pathways and concussion severity : a genetic association study | en_ZA |
dc.type | Postprint Article | en_ZA |