The role of reactive oxygen species in adipogenic differentiation

Show simple item record De Villiers, Danielle Potgieter, Marnie Ambele, Melvin Anyasi Adam, Ladislaus Durandt, Chrisna Pepper, Michael Sean 2019-01-31T04:47:47Z 2019-01-31T04:47:47Z 2017-11
dc.description.abstract Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess accumulation of adipose tissue. Obesity is a major risk factor for complex disorders such as cancer, type 2 diabetes, and cardiovascular diseases. The ability of mesenchymal stromal/stem cells (MSCs) to differentiate into adipocytes is often used as a model for studying adipogenesis in vitro. A key focus is the effect of both intra- and extracellular reactive oxygen species (ROS) on adipogenesis. The consensus from the majority of studies is that ROS, irrespective of the source, promote adipogenesis. The effect of ROS on adipogenesis is suppressed by antioxidants or ROS scavengers. Reactive oxygen species are generated during the process of adipocyte differentiation as well as by other cell metabolic processes. Despite many studies in this field, it is still not possible to state with certainty whether ROS measured during adipocyte differentiation are a cause or consequence of this process. In addition, it is still unclear what the exact sources are of the ROS that initiate and/or drive adipogenic differentiation in MSCs in vivo. This review provides an overview of our understanding of the role of ROS in adipocyte differentiation as well as how certain ROS scavengers and antioxidants might affect this process. en_ZA
dc.description.department Genetics en_ZA
dc.description.department Immunology en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship The South African Medical Research Council in terms of the SAMRC's Flagship Award Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Unit for Stem Cell Research and Therapy and the Institute for Cellular and Molecular Medicine of the University of Pretoria. en_ZA
dc.description.uri http://www.springer.comseries/5584 en_ZA
dc.identifier.citation De Villiers D., Potgieter M., Ambele M.A., Adam L., Durandt C., Pepper M.S. (2017) The Role of Reactive Oxygen Species in Adipogenic Differentiation. In: Van Pham P. (eds) Stem Cells: Biology and Engineering. Advances in Experimental Medicine and Biology, vol 1083. Springer, Cham. en_ZA
dc.identifier.issn 0065-2598
dc.identifier.other 10.1007/5584_2017_119
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Springer International Publishing AG 2017.The original publication is available at : http://www.springer.comseries/5584. en_ZA
dc.subject Adipogenic differentiation en_ZA
dc.subject Adipose-derived stromal cells en_ZA
dc.subject Reactive oxygen species en_ZA
dc.subject ROS scavengers en_ZA
dc.subject Mesenchymal stromal/stem cells (MSCs) en_ZA
dc.subject Reactive oxygen species (ROS) en_ZA
dc.title The role of reactive oxygen species in adipogenic differentiation en_ZA
dc.type Postprint Article en_ZA

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