Contrasting views on the role of mesenchymal stromal/stem cells in tumour growth : a systematic review of experimental design

Show simple item record Oloyo, Ahmed Kolade Ambele, Melvin Anyasi Pepper, Michael Sean 2019-01-30T11:14:07Z 2019-01-30T11:14:07Z 2017-11
dc.description.abstract The effect of mesenchymal stromal/stem cells (MSCs) on tumour growth remains controversial. Experimental evidence supports both an inhibitory and a stimulatory effect. We have assessed factors responsible for the contrasting effects of MSCs on tumour growth by doing a meta-analysis of existing literature between 2000 and May 2017. We assessed 183 original research articles comprising 338 experiments. We considered (a) in vivo and in vitro experiments, (b) whether in vivo studies were syngeneic or xenogeneic, and (c) if animals were immune competent or deficient. Furthermore, the sources and types of cancer cells and MSCs were considered together with modes of cancer induction and MSC administration. 56% of all 338 experiments reported that MSCs promote tumour growth. 78% and 79% of all experiments sourced human MSCs and cancer cells, respectively. MSCs were used in their naïve and engineered form in 86% and 14% of experiments, respectively, the latter to produce factors that could alter either their activity or that of the tumour. 53% of all experiments were conducted in vitro with 60% exposing cancer cells to MSCs via coculture. Of all in vivo experiments, 79% were xenogeneic and 63% were conducted in immune-competent animals. Tumour growth was inhibited in 80% of experiments that used umbilical cord-derived MSCs, whereas tumour growth was promoted in 64% and 57% of experiments that used bone marrow- and adipose tissue-derived MSCs, respectively. This contrasting effect of MSCs on tumour growth observed under different experimental conditions may reflect differences in experimental design. This analysis calls for careful consideration of experimental design given the large number of MSC clinical trials currently underway. en_ZA
dc.description.department Immunology en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship The South African Medical Research Council in terms of the SAMRC’s Flagship Award Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Stem Cell Research and Therapy Unit, the National Research Foundation of South Africa (grant no. 86942), the National Health Laboratory Services Research Trust (grant no. 94453), the University of Pretoria Research Development Programme (A0Z778), the University of Pretoria Vice Chancellor’s Postdoctoral Fellowship and the Institute for Cellular and Molecular Medicine of the University of Pretoria. en_ZA
dc.description.uri http://www.springer.comseries/5584 en_ZA
dc.identifier.citation Oloyo A.K., Ambele M.A., Pepper M.S. (2017) Contrasting Views on the Role of Mesenchymal Stromal/Stem Cells in Tumour Growth: A Systematic Review of Experimental Design. In: Van Pham P. (eds) Stem Cells: Biology and Engineering. Advances in Experimental Medicine and Biology, vol 1083. Springer, Cham. en_ZA
dc.identifier.issn 0065-2598
dc.identifier.other 10.1007/5584_2017_118
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Springer International Publishing AG 2017.The original publication is available at : http://www.springer.comseries/5584. en_ZA
dc.subject Mesenchymal stromal/stem cells (MSCs) en_ZA
dc.subject Cancer en_ZA
dc.subject Syngeneic en_ZA
dc.subject Xenogeneic en_ZA
dc.subject Adipose tissue en_ZA
dc.subject Bone marrow en_ZA
dc.subject Carcinogenesis en_ZA
dc.subject Clinical trial (topic) en_ZA
dc.subject Coculture en_ZA
dc.subject Experimental design en_ZA
dc.subject In vivo study en_ZA
dc.subject Tumor growth en_ZA
dc.subject Umbilical cord en_ZA
dc.title Contrasting views on the role of mesenchymal stromal/stem cells in tumour growth : a systematic review of experimental design en_ZA
dc.type Postprint Article en_ZA

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