Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications

Show simple item record Wolmarans, Elize Boy, S.C. (Sonja) Nel, Sulette Mercier, Anne Elisabeth Pepper, Michael Sean 2019-01-30T10:48:04Z 2019-01-30T10:48:04Z 2017-11
dc.description.abstract The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including solid and hematological tumors). CSCs are characterized by their capacity for self-renewal, their ability to introduce heterogeneity within a tumor mass and its metastases, genomic instability, and their insensitivity to both radiation and chemotherapy. The latter highlights the clinical importance of studying this subpopulation since their resistance to traditional treatments may lead to metastatic disease and/or tumor relapse. Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignancy worldwide with the highest incidence occurring in East Asia and eastern and southern Africa. Several cellular subpopulations believed to have CSC properties have been isolated from HNSCCs, but at present, identification and characterization of CSCs remains an experimental challenge with no established or standardized protocols in place to confirm their identity. In this review we discuss current approaches to the study of CSCs with a focus on HNSCCs, particularly in the context of what this might mean from a therapeutic perspective. en_ZA
dc.description.department Immunology en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship The South African Medical Research Council in terms of the SAMRC’s Flagship Award Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Unit for Stem Cell Research and Therapy and the Institute for Cellular and Molecular Medicine of the University of Pretoria. en_ZA
dc.description.uri http://www.springer.comseries/5584 en_ZA
dc.identifier.citation Wolmarans E., Boy S.C., Nel S., Mercier A.E., Pepper M.S. (2017) Cancer Stem Cells in Head and Neck Carcinomas: Identification and Possible Therapeutic Implications. In: Van Pham P. (eds) Stem Cells: Biology and Engineering. Advances in Experimental Medicine and Biology, vol 1083. Springer, Cham. en_ZA
dc.identifier.issn 0065-2598
dc.identifier.other 10.1007/5584_2017_116
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Springer International Publishing AG 2017.The original publication is available at : http://www.springer.comseries/5584. en_ZA
dc.subject Head carcinoma en_ZA
dc.subject Neck carcinoma en_ZA
dc.subject Cancer stem cells (CSCs) en_ZA
dc.subject Head and neck squamous cell carcinomas (HNSCCs) en_ZA
dc.title Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications en_ZA
dc.type Postprint Article en_ZA

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