dc.contributor.author |
Ambele, Melvin Anyasi
|
|
dc.contributor.author |
Pepper, Michael Sean
|
|
dc.contributor.author |
Van Heerden, Marlene B.
|
|
dc.contributor.author |
Van Heerden, Willem Francois Petrus
|
|
dc.date.accessioned |
2019-01-29T12:55:20Z |
|
dc.date.issued |
2019-05 |
|
dc.description.abstract |
BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different sections of the same HPV negative tumor on the floor of mouth in a patient with history of prolonged smoking.
METHODS : Histological examination, presence of HPV infection and OncoScan analysis of DNA extracted from two well‐defined areas with different p16 expression profiles were performed. RESULTS : Histological and immunochemical analysis revealed the presence of a dual architectural pattern squamous cell carcinoma with a p16 negative and a p16 positive component. OncoScan analysis showed genetic changes that define field cancerization of the p16 negative tumor as revealed by mosaicism in both loss of heterozygosity and copy number alterations in cancer‐associated genes located on 3p, 7p, 9p 11q, and 17p.
CONCLUSION : These changes were indicative of field cancerization in response to tobacco exposure. |
en_ZA |
dc.description.department |
Immunology |
en_ZA |
dc.description.department |
Oral Pathology and Oral Biology |
en_ZA |
dc.description.embargo |
2019-12-14 |
|
dc.description.librarian |
hj2019 |
en_ZA |
dc.description.sponsorship |
South African Medical Research Council (MSP);
Cancer Association of South Africa (WFPvH) |
en_ZA |
dc.description.uri |
http://wileyonlinelibrary.com/journal/hed |
en_ZA |
dc.identifier.citation |
Ambele MA, Pepper MS,
van Heerden MB, van Heerden WFP. Heterozygosity
of p16 expression in an oral squamous cell carcinoma
with associated loss of heterozygosity and copy number
alterations. Head & Neck. 2019;41:E62–E65. https://doi.org/10.1002/hed.25566. |
en_ZA |
dc.identifier.issn |
1043-3074 (print) |
|
dc.identifier.issn |
1097-0347 (online) |
|
dc.identifier.other |
10.1002/hed.25566 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/68294 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2018 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : Heterozygosity
of p16 expression in an oral squamous cell carcinoma
with associated loss of heterozygosity and copy number
alterations. Head and Neck, vol. 41, no. 5, pp. E62-E65, 2019, doi : 10.1002/hed.25566. The definite version is available at : http://wileyonlinelibrary.com/journal/hed. |
en_ZA |
dc.subject |
Carcinogenesis |
en_ZA |
dc.subject |
Field cancerization |
en_ZA |
dc.subject |
OncoScan analysis |
en_ZA |
dc.subject |
Oral cancer |
en_ZA |
dc.subject |
P16 expression |
en_ZA |
dc.title |
Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations |
en_ZA |
dc.type |
Postprint Article |
en_ZA |