Molecular biomarkers for gestational diabetes mellitus

Show simple item record Dias, Stephanie Pheiffer, Carmen Abrahams, Yoonus Rheeder, Paul Adam, Sumaiya 2019-01-15T08:35:00Z 2019-01-15T08:35:00Z 2018-09-26
dc.description.abstract Gestational diabetes mellitus (GDM) is a growing public health problem worldwide. The condition is associated with perinatal complications and an increased risk for future metabolic disease in both mothers and their offspring. In recent years, molecular biomarkers received considerable interest as screening tools for GDM. The purpose of this review is to provide an overview of the current status of single-nucleotide polymorphisms (SNPs), DNA methylation, and microRNAs as biomarkers for GDM. PubMed, Scopus, and Web of Science were searched for articles published between January 1990 and August 2018. The search terms included “gestational diabetes mellitus”, “blood”, “single-nucleotide polymorphism (SNP)”, “DNA methylation”, and “microRNAs”, including corresponding synonyms and associated terms for each word. This review updates current knowledge of the candidacy of these molecular biomarkers for GDM with recommendations for future research avenues. en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.uri en_ZA
dc.identifier.citation Dias, S., Pheiffer, C., Abrahams, Y. et al. 2018, 'Molecular biomarkers for gestational diabetes mellitus', International Journal of Molecular Sciences, vol. 19, no. 10, art. 2926, pp. 1-27. en_ZA
dc.identifier.issn 1422-0067 (online)
dc.identifier.other 10.3390/ijms19102926
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2018 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license. en_ZA
dc.subject Molecular biomarkers en_ZA
dc.subject DNA methylation en_ZA
dc.subject MicroRNAs en_ZA
dc.subject Genetic and epigenetic markers en_ZA
dc.subject Gestational diabetes mellitus (GDM) en_ZA
dc.subject Single-nucleotide polymorphism (SNP) en_ZA
dc.title Molecular biomarkers for gestational diabetes mellitus en_ZA
dc.type Article en_ZA

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