Analysis of gonadotrophin‐releasing hormone‐1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant‐shrew (Elephantulus myurus)

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dc.contributor.author Medger, Katarina
dc.contributor.author Bennett, Nigel C., 1961-
dc.contributor.author Chimimba, Christian Timothy
dc.contributor.author Oosthuizen, Maria Kathleen
dc.contributor.author Mikkelsen, Jens D.
dc.contributor.author Coen, Clive W.
dc.date.accessioned 2018-10-31T12:08:39Z
dc.date.issued 2018-10
dc.description.abstract Of the 18 sub‐Saharan elephant‐shrew species, only eastern rock elephant‐shrews reproduce seasonally throughout their distribution, a process seemingly independent of photoperiod. The present study characterizes gonadal status and location/intensity of gonadotrophin‐releasing hormone‐1 (GnRH‐1) and kisspeptin immunoreactivities in this polyovulating species in the breeding and nonbreeding seasons. GnRH‐1‐immunoreactive (ir) cell bodies are predominantly in the medial septum, diagonal band, and medial preoptic area; processes are generally sparse except in the external median eminence. Kisspeptin‐ir cell bodies are detected only within the arcuate nucleus; the density of processes is generally low, except in the septohypothalamic nucleus, ventromedial bed nucleus of the stria terminalis, arcuate nucleus, and internal and external median eminence. Kisspeptin‐ir processes are negligible at locations containing GnRH‐1‐ir cell bodies. The external median eminence is the only site with conspicuously overlapping distributions of the respective immunoreactivities and, accordingly, a putative site for kisspeptin's regulation of GnRH‐1 release in this species. In the nonbreeding season in males, there is an increase in the rostral population of GnRH‐1‐ir cell bodies and density of GnRH‐1‐ir processes in the median eminence. In both sexes, the breeding season is associated with increased kisspeptin‐ir process density in the rostral periventricular area of the third ventricle and arcuate nucleus; at the latter site, this is positively correlated with gonadal mass. Cross‐species comparisons lead us to hypothesize differential mechanisms within these peptidergic systems: that increased GnRH‐1 immunoreactivity during the nonbreeding season reflects increased accumulation with reduced release; that increased kisspeptin immunoreactivity during the breeding season reflects increased synthesis with increased release. en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.embargo 2019-10-15
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship Augustinus Fonden; Biotechnology and Biological Sciences Research Council, Grant/Award Number: BBD5231861; South African National Research Foundation. en_ZA
dc.description.uri http://wileyonlinelibrary.com/journal/cne en_ZA
dc.identifier.citation Medger K, Bennett NC, Chimimba CT, Oosthuizen MK, Mikkelsen JD, Coen CW. Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus). Journal of Comparative Neurology. 2018;526:2388–2405. https://doi.org/10.1002/cne.24498. en_ZA
dc.identifier.issn 0021-9967 (print)
dc.identifier.issn 1096-9861 (online)
dc.identifier.other 10.1002/cne.24498
dc.identifier.uri http://hdl.handle.net/2263/67108
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2018 Wiley Periodicals Inc. This is the pre-peer reviewed version of the following article : Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus). Journal of Comparative Neurology. 2018;526:2388–2405. https://doi.org/10.1002/cne.24498. The definite version is available at : http://wileyonlinelibrary.com/journal/cne. en_ZA
dc.subject Gonadotrophin‐releasing hormone‐1 (GnRH‐1) en_ZA
dc.subject Afrotheria en_ZA
dc.subject Anteroventral periventricular nucleus (AVPV) en_ZA
dc.subject Arcuate nucleus en_ZA
dc.subject Kisspeptin en_ZA
dc.subject RRID:AB_2315026 en_ZA
dc.subject RRID:AB_2631061 en_ZA
dc.subject RRID:AB_572248 en_ZA
dc.subject RRID:SCR_002865 en_ZA
dc.subject RRID:SCR_003070 en_ZA
dc.subject RRID:SCR_014199 en_ZA
dc.subject Seasonal reproduction en_ZA
dc.subject Eastern rock elephant‐shrews (Elephantulus myurus) en_ZA
dc.title Analysis of gonadotrophin‐releasing hormone‐1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant‐shrew (Elephantulus myurus) en_ZA
dc.type Postprint Article en_ZA


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