Medicinal Mascarene Aloes : an audit of their phytotherapeutic potential

Show simple item record Lobine, Devina Cummins, Ian Govinden-Soulange, Joyce Ranghoo-Sanmukhiya, Mala Lindsey, Keith Chazot, Paul Louis Ambler, C.A. Grellscheid, Sushma Sharples, G. Lall, Namrita Lambrechts, Isa Anina Lavergne, Christophe Howes, Melanie Jayne R. 2018-10-29T08:54:52Z 2018-01
dc.description.abstract A phytochemical and biological investigation of the endemic Mascarene Aloes (Aloe spp.), including A. tormentorii (Marais) L.E.Newton & G.D.Rowley, A. purpurea Lam, A. macra Haw., A. lomatophylloides Balf.f and A. vera (synonym A. barbadensis Mill.), which are used in the traditional folk medicine of the Mascarene Islands, was initiated. Methanolic extracts of the Aloes under study were analysed using high resolution LC-UV-MS/MS and compounds belonging to the class of anthraquinones, anthrones, chromones and flavone C-glycosides were detected. The Mascarene Aloes could be distinguished from A. vera by the absence of 2″-O-feruloylaloesin and 7-O-methylaloeresin. GC–MS analysis of monosaccharides revealed the presence of arabinose, fucose, xylose, mannose and galactose in all the Mascarene Aloes and in A. vera. The crude extracts of all Aloes analysed displayed antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Only extracts of A. macra were active against P. aeruginosa and Klebsiella pneumoniae, while none of the Aloe extracts inhibited Propionibacterium acnes. A. macra displayed anti-tyrosinase activity, exhibiting 50% inhibition at 0.95 mg/mL, and extracts of A. purpurea (Mauritius) and A. vera displayed activity in a wound healing-scratch assay. In vitro cytotoxicity screening of crude methanolic extracts of the Aloes, using the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) showed that only A. purpurea (Réunion) elicited a modest toxic effect against HL60 cells, with a percentage toxicity of 8.2% (A. purpurea-Réunion) and none of the Aloe extracts elicited a toxic effect against MRC 5 fibroblast cells at a concentration of 0.1 mg/mL. Mascarene Aloe species possess noteworthy pharmacological attributes associated with their rich phytochemical profiles. en_ZA
dc.description.department Plant Production and Soil Science en_ZA
dc.description.embargo 2019-01-01
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship The Commonwealth Scholarship Commission (MUCN-2013-124); the Durham Biophysical Sciences Institute 1 + 1 Fellowship at Durham University and Tertiary Education Commission (Mauritius). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Lobine, D., Cummins, I., Govinden-Soulange, J. et al. 2018, 'Medicinal Mascarene Aloes: an audit of their phytotherapeutic potential', Fitoterapia, vol. 124, pp. 120-126. en_ZA
dc.identifier.issn 0367-326X
dc.identifier.other 10.1016/j.fitote.2017.10.010
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Fitoterapia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Fitoterapia, vol. 124, pp. 120-126, 2018. doi : 10.1016/j.fitote.2017.10.010. en_ZA
dc.subject Mascarene Aloes en_ZA
dc.subject Biological activity en_ZA
dc.subject Liquid chromatography–mass spectrometry (LC-MS) en_ZA
dc.subject Gas chromatography–mass spectrometry (GC-MS) en_ZA
dc.subject Monosaccharides en_ZA
dc.subject Anthraquinone derivative en_ZA
dc.subject Antibiotic agent en_ZA
dc.subject Arabinose en_ZA
dc.subject Chromone derivative en_ZA
dc.subject Flavone derivative en_ZA
dc.subject Fucose en_ZA
dc.subject Galactose en_ZA
dc.subject Mannose en_ZA
dc.subject Plant extract en_ZA
dc.subject Plant medicinal product en_ZA
dc.subject Unclassified drug en_ZA
dc.subject Xylose en_ZA
dc.subject Antibacterial activity en_ZA
dc.subject Bacillus cereus en_ZA
dc.subject Escherichia coli en_ZA
dc.subject HaCat cell line en_ZA
dc.subject HL-60 cell line en_ZA
dc.subject Human cell en_ZA
dc.subject In vitro study en_ZA
dc.subject Klebsiella pneumoniae en_ZA
dc.subject Mass fragmentography en_ZA
dc.subject Promyelocytic leukemia en_ZA
dc.subject Propionibacterium en_ZA
dc.subject Pseudomonas aeruginosa en_ZA
dc.subject Staphylococcus aureus en_ZA
dc.subject Wound healing en_ZA
dc.title Medicinal Mascarene Aloes : an audit of their phytotherapeutic potential en_ZA
dc.type Postprint Article en_ZA

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