A two-year monitoring period of the genetic properties of clade 2.3.2.1c H5N1 viruses in Nigeria reveals the emergence and co-circulation of distinct genotypes

Show simple item record

dc.contributor.author Laleye, Agnes Tinuke
dc.contributor.author Joannis, Tony Manuel
dc.contributor.author Shittu, Ismaila
dc.contributor.author Meseko, Clement Adebajo
dc.contributor.author Zamperin, Gianpiero
dc.contributor.author Milani, Adelaide
dc.contributor.author Zecchin, Bianca
dc.contributor.author Fusaro, Alice
dc.contributor.author Monne, Isabella
dc.contributor.author Abolnik, Celia
dc.date.accessioned 2018-10-19T12:05:34Z
dc.date.issued 2018-01
dc.description.abstract Phylogenetic analyses of the complete genomes of the highly pathogenic avian influenza (HPAI) 2.3.2.1c H5N1 virus strains causing outbreaks in Nigeria's poultry population from 2014 to 2016 showed evidence of distinct co-circulating genotypes and the emergence of reassortant viruses. One of these reassortants became the predominant strain by 2016, and the NA protein of this strain possessed the V96A substitution known to confer reduced susceptibility to neuraminidase inhibiting antiviral drugs. Our findings also demonstrated evolutionary relationships between Nigerian isolates and European and Middle Eastern strains of H5N1 which provides further evidence for the proposed role of migratory birds in spreading the virus, although the involvement of the live poultry trade cannot be excluded. Efforts must be directed towards improving biosecurity and gaining the cooperation of poultry farmers for more effective control of HPAI, in order to mitigate the emergence of HPAI strains in Nigeria with biological properties that are potentially even more dangerous to animals and humans. en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.embargo 2019-01-01
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship This work was supported by the Food and Agriculture Organization of the United Nations (UN-FAO) with funding from the United States Agency for International Development (USAID) under the OSRO/GLO/501/USA project entitled “Emergency Assistance for prevention and control of H5N1 HPAI in West and Central Africa”. en_ZA
dc.description.uri http://www.elsevier.com/locate/meegid en_ZA
dc.identifier.citation Laleye, A., Joannis, T., Shittu, I. et al. 2018, 'A two-year monitoring period of the genetic properties of clade 2.3.2.1c H5N1 viruses in Nigeria reveals the emergence and co-circulation of distinct genotypes', Infection, Genetics and Evolution, vol. 57, pp. 98-105. en_ZA
dc.identifier.issn 1567-1348 (print)
dc.identifier.issn 1567-7257 (online)
dc.identifier.other 10.1016/j.meegid.2017.10.027
dc.identifier.uri http://hdl.handle.net/2263/66953
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2018 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Infection, Genetics and Evolution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Infection, Genetics and Evolution, vol. 57, pp. 98-105, 2018, doi : 10.1016/j.meegid.2017.10.027. en_ZA
dc.subject Highly pathogenic avian influenza (HPAI) en_ZA
dc.subject Full-genome sequencing en_ZA
dc.subject Co-circulation en_ZA
dc.subject Reassortment en_ZA
dc.subject Mutation en_ZA
dc.subject Evolution en_ZA
dc.subject Antivirus agent en_ZA
dc.subject Sialidase inhibitor en_ZA
dc.subject Unclassified drug en_ZA
dc.subject Viral protein NA en_ZA
dc.subject Amino acid substitution en_ZA
dc.subject Animal tissue en_ZA
dc.subject Antiviral susceptibility en_ZA
dc.subject Avian influenza en_ZA
dc.subject Avian influenza (H5N1) en_ZA
dc.subject Chicken en_ZA
dc.subject Cladistics en_ZA
dc.subject Embryo en_ZA
dc.subject Enzyme inhibition en_ZA
dc.subject Epidemic en_ZA
dc.subject Europe en_ZA
dc.subject Genotype en_ZA
dc.subject Virus transmission en_ZA
dc.subject Virus genome en_ZA
dc.subject Viral genetics en_ZA
dc.subject Unindexed sequence en_ZA
dc.subject Phylogeny en_ZA
dc.subject Nonhuman en_ZA
dc.subject Nigeria en_ZA
dc.subject Migrant bird en_ZA
dc.subject Middle East en_ZA
dc.title A two-year monitoring period of the genetic properties of clade 2.3.2.1c H5N1 viruses in Nigeria reveals the emergence and co-circulation of distinct genotypes en_ZA
dc.type Postprint Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record