A two-year monitoring period of the genetic properties of clade 2.3.2.1c H5N1 viruses in Nigeria reveals the emergence and co-circulation of distinct genotypes

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Authors

Laleye, Agnes Tinuke
Joannis, Tony Manuel
Shittu, Ismaila
Meseko, Clement Adebajo
Zamperin, Gianpiero
Milani, Adelaide
Zecchin, Bianca
Fusaro, Alice
Monne, Isabella
Abolnik, Celia

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Volume Title

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Elsevier

Abstract

Phylogenetic analyses of the complete genomes of the highly pathogenic avian influenza (HPAI) 2.3.2.1c H5N1 virus strains causing outbreaks in Nigeria's poultry population from 2014 to 2016 showed evidence of distinct co-circulating genotypes and the emergence of reassortant viruses. One of these reassortants became the predominant strain by 2016, and the NA protein of this strain possessed the V96A substitution known to confer reduced susceptibility to neuraminidase inhibiting antiviral drugs. Our findings also demonstrated evolutionary relationships between Nigerian isolates and European and Middle Eastern strains of H5N1 which provides further evidence for the proposed role of migratory birds in spreading the virus, although the involvement of the live poultry trade cannot be excluded. Efforts must be directed towards improving biosecurity and gaining the cooperation of poultry farmers for more effective control of HPAI, in order to mitigate the emergence of HPAI strains in Nigeria with biological properties that are potentially even more dangerous to animals and humans.

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Keywords

Highly pathogenic avian influenza (HPAI), Full-genome sequencing, Co-circulation, Reassortment, Mutation, Evolution, Antivirus agent, Sialidase inhibitor, Unclassified drug, Viral protein NA, Amino acid substitution, Animal tissue, Antiviral susceptibility, Avian influenza, Avian influenza (H5N1), Chicken, Cladistics, Embryo, Enzyme inhibition, Epidemic, Europe, Genotype, Virus transmission, Virus genome, Viral genetics, Unindexed sequence, Phylogeny, Nonhuman, Nigeria, Migrant bird, Middle East

Sustainable Development Goals

Citation

Laleye, A., Joannis, T., Shittu, I. et al. 2018, 'A two-year monitoring period of the genetic properties of clade 2.3.2.1c H5N1 viruses in Nigeria reveals the emergence and co-circulation of distinct genotypes', Infection, Genetics and Evolution, vol. 57, pp. 98-105.