Discordant calcium and parathyroid hormone with presumed epileptic seizures

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dc.contributor.author Chale-Matsau, Bettina
dc.contributor.author Van Niekerk, Chantal
dc.contributor.author Kemp, Tanja
dc.contributor.author Pillay, Tahir S.
dc.date.accessioned 2018-09-12T09:45:17Z
dc.date.issued 2018-03
dc.description.abstract A 33-year-old woman presented for the first time at the age of 9 years with recurrent seizures and was subsequently treated for epilepsy for 2 years. At 11 years of age, it was noted that the patient had hypocalcemia with an increased parathyroid hormone (PTH) measured with use of an intact PTH assay. Serum calcium was 5.73 mg/dL [1.43 mmol/L; reference interval (RI) 8.82–10.42 mg/dL (2.2–2.6 mmol/L)]; serum phosphate was 10.42 mg/dL [3.36 mmol/L; RI 1.86–4.34 mg/dL (0.6 –1.4 mmol/L)]; and PTH was 319.68 pg/mL [33.9 pmol/L; RI 8.49–68.84 pg/mL (0.9 –7.3 mmol/ L)]. Vitamin D (Total 25-OH; 25-OH D2 and D3) concentrations, magnesium concentrations, liver and renal function tests were all normal. No other endocrine abnormalities such as thyroid or gonadotropin resistance were detected. The patient also was of short stature and was overweight. However, she became overweight after the age of 13 years (body mass index at 13 years was 22.8 kg/m2), and the short stature was not significant, as she was at the lower end of the RI for height at 1.55 m. There was no cognitive impairment. Positive Chvostek sign was observed but not Trousseau sign. en_ZA
dc.description.department Chemical Pathology en_ZA
dc.description.embargo 2019-03-01
dc.description.librarian am2018 en_ZA
dc.description.uri https://www.aacc.org/publications/clinical-chemistry en_ZA
dc.identifier.citation Chale-Matsau, B., Van Niekerk, C., Kemp, T. & Pillay, T.S. 2018, 'Discordant calcium and parathyroid hormone with presumed epileptic seizures', Clinical Chemistry, vol. 64, no. 3, pp. 442-446. en_ZA
dc.identifier.issn 0009-9147 (print)
dc.identifier.issn 1530-8561 (online)
dc.identifier.other 10.1373/clinchem.2016.269555
dc.identifier.uri http://hdl.handle.net/2263/66544
dc.language.iso en en_ZA
dc.publisher American Association for Clinical Chemistry en_ZA
dc.rights © 2018 American Association for Clinical Chemistry en_ZA
dc.subject Woman en_ZA
dc.subject Vitamin D en_ZA
dc.subject Epilepsy en_ZA
dc.subject Parathyroid hormone (PTH) en_ZA
dc.subject Reference interval (RI) en_ZA
dc.subject Pseudohypoparathyroidism en_ZA
dc.title Discordant calcium and parathyroid hormone with presumed epileptic seizures en_ZA
dc.type Article en_ZA


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