Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

Show simple item record Gwangwa, Mokgadi Violet Joubert, Anna Margaretha Visagie, M.H. (Michelle Helen) 2018-09-07T10:07:10Z 2018-09-07T10:07:10Z 2018-05-04
dc.description.abstract Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione. Several stimuli including cells deprived of nutrients or failure of antioxidant systems result in oxidative stress and cell death induction. Among the cell death machinery is autophagy, a compensatory mechanism whereby energy is produced from damaged and/or redundant organelles and proteins, which prevents the accumulation of waste products, thereby maintaining homeostasis. Furthermore, autophagy is maintained by several pathways including phosphoinositol 3 kinases, the mitogen-activated protein kinase family, hypoxia-inducible factor, avian myelocytomatosis viral oncogene homolog and protein kinase receptor-like endoplasmic reticulum kinase. The persistent potential of cancer metabolism, redox regulation and the crosstalk with autophagy in scientific investigation pertains to its ability to uncover essential aspects of tumourigenic transformation. This may result in clinical translational possibilities to exploit tumourigenic oxidative status and autophagy to advance our capabilities to diagnose, monitor and treat cancer. en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian am2018 en_ZA
dc.description.sponsorship Grants from the Cancer Association of South Africa, the Medical Research Council, the National Research Foundation, Struwig Germeshuysen Trust and the School of Medicine Research Committee of the Faculty of Health Sciences, University of Pretoria. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Gwangwa, M.V., Joubert, A.M. & Visagie, M.H. 2018, 'Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis', Cellular and Molecular Biology Letters, vol. 23, art. no. 20, pp. 1-19. en_ZA
dc.identifier.issn 1425-8153 (print)
dc.identifier.issn 1689-1392 (online)
dc.identifier.other 10.1186/s11658-018-0088-y
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( en_ZA
dc.subject Warburg effect en_ZA
dc.subject Autophagy en_ZA
dc.subject Oxidative stress en_ZA
dc.subject Cancer en_ZA
dc.subject Prostate cancer en_ZA
dc.subject Reactive oxygen species (ROS) en_ZA
dc.subject Mitochondrial mass en_ZA
dc.subject Glutamine metabolism en_ZA
dc.subject Therapeutic strategies en_ZA
dc.subject Tumor growth en_ZA
dc.subject Cancer stem cells (CSCs) en_ZA
dc.title Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis en_ZA
dc.type Article en_ZA

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