The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in vultures

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dc.contributor.author Adawaren, Emmanuel Oluwasegun
dc.contributor.author Mukandiwa, Lillian
dc.contributor.author Njoya, Emmanuel Mfotie
dc.contributor.author Bekker, Lizette
dc.contributor.author Duncan, N.M. (Neil)
dc.contributor.author Naidoo, Vinny
dc.date.accessioned 2018-08-02T11:57:12Z
dc.date.issued 2018-09
dc.description.abstract Diclofenac, a non-steroidal anti-inflammatory drug (NSAID) was responsible for the death of millions of vultures on the Asian subcontinent, following the consumption of diclofenac contaminated carcasses. The aim of this research was to establish if liver slices could serve as an alternate means of predicting the toxicity of NSAIDs in Gyps vultures. The Cape vulture liver slices was prepared and incubated with four NSAIDs for 6 h. A percent clearance of 1.0 ± 0.253, 0.58 ± 0.153, 0.961 ± 0.312 and 1.242 ± 0.406 (%/h*g) was attained for diclofenac, carprofen, ketoprofen and meloxicam respectively. Both meloxicam and diclofenac exerted toxic effects on the hepatic cells. Protein content indicated that the vulture tissue had lower enzyme levels than expected for an animal of its size. The poor distinction between the ex vivo hepatic percent clearance of meloxicam and diclofenac indicates that liver slices is not an ideal model to investigate NSAIDs toxicity in Cape vulture. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.embargo 2019-09-01
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship The National Research Foundation (NRF) of South Africa (Grant no 87772 ). en_ZA
dc.description.uri http://www.elsevier.com/locate/etap en_ZA
dc.identifier.citation Adawaren, E.O., Mukandiwa, L., Njoya, E.M. 2018, 'The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in vultures', Environmental Toxicology and Pharmacology, vol. 62, pp. 147-155. en_ZA
dc.identifier.issn 1382-6689 (print)
dc.identifier.issn 1872-7077 (online)
dc.identifier.other 10.1016/j.etap.2018.07.001
dc.identifier.uri http://hdl.handle.net/2263/66064
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2018 Elsevier B.V.. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 62, pp. 147-155, 2018. doi : 10.1016/j.etap.2018.07.001. en_ZA
dc.subject Diclofenac en_ZA
dc.subject Meloxicam en_ZA
dc.subject Liver slices en_ZA
dc.subject Cape vulture (Gyps coprotheres) en_ZA
dc.subject Percent clearance en_ZA
dc.subject Toxicity en_ZA
dc.subject Non-steroidal anti-inflammatory drug (NSAID) en_ZA
dc.title The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in vultures en_ZA
dc.type Postprint Article en_ZA


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