Genital Chlamydia trachomatis and Neisseria gonorrhoeae infections among women in sub-Saharan Africa : a structured review

Show simple item record Dubbink, Jan Henk Verweij, Stephan P. Struthers, Helen E. Ouburg, Sander McIntyre, James A. Morre, Servaas A. Peters, Remco P.H. 2018-07-10T12:43:45Z 2018-07-10T12:43:45Z 2018-07
dc.description.abstract Chlamydia trachomatis and Neisseria gonorrhoeae constitute major public health problems among women, but the burden of infection in sub-Saharan Africa is poorly documented. We conducted a structured review of the prevalence and incidence of genital, oral and anal C. trachomatis and N. gonorrhoeae infection in women in sub-Saharan Africa. We searched Medline, EMBASE and Web of Science over a 10-year period for studies on epidemiology of genital, oral and anal chlamydial infection and gonorrhoea in women in all countries of sub-Saharan Africa. We assessed geographic and demographic differences in prevalence and incidence of infection; weighted mean prevalence estimates were calculated with a random-effect model. A total of 102 study results were included, with data available for 24/49 of sub-Saharan countries. The weighted prevalence of chlamydial infection was lower among women in community-based studies (3.9%; 95% CI: 2.9–5.1%) than for women recruited at primary healthcare facilities (6.0%; 95% CI: 4.2–8.4%, p < 0.001); the same was observed for gonorrhoea (2.2%; 95% CI: 1.2–4.0% vs. 4.2%; 95% CI: 3.2–5.6%, p < 0.001). Prevalence of Chlamydia among sex workers was 5.5% (95% CI: 4.2–7.3%) and gonorrhoea 7.6% (95% CI: 5.4–11%). Seven studies reported on incidence which varied between 0.75–28 and 2.8–17 per 100 person-years-at-risk for chlamydial infection and gonorrhoea, respectively. Only two studies reported on anal infections and one on oral infection. This overview underscores the considerable incidence and prevalence of genital C. trachomatis and N. gonorrhoeae in women in different settings in sub-Saharan Africa. Better control strategies are warranted to reduce the burden of infection and to prevent long-term complications of these infections. en_ZA
dc.description.department Medical Microbiology en_ZA
dc.description.librarian hj2018 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Dubbink, J.H., Verweij, S.P., Struthers, H.E. et al. 2018, 'Genital Chlamydia trachomatis and Neisseria gonorrhoeae infections among women in sub-Saharan Africa : a structured review', International Journal of STD and AIDS, vol. 29, no. 8, pp. 806-824. en_ZA
dc.identifier.issn 0956-4624 (print)
dc.identifier.issn 1758-1052 (online)
dc.identifier.other 10.1177/0956462418758224
dc.language.iso en en_ZA
dc.publisher Sage en_ZA
dc.rights © The Author(s) 2018 en_ZA
dc.subject Condom use en_ZA
dc.subject Chlamydia trachomatis en_ZA
dc.subject Neisseria gonorrhoeae en_ZA
dc.subject Sexually transmitted infection (STI) en_ZA
dc.subject Epidemiology en_ZA
dc.subject Sub-Saharan Africa en_ZA
dc.subject Women en_ZA
dc.subject Low-resource setting en_ZA
dc.subject Female sex workers en_ZA
dc.subject Reproductive tract infections (RTIs) en_ZA
dc.subject Western Cape Province, South Africa en_ZA
dc.subject Simplex virus type 2 en_ZA
dc.subject Rural South Africa en_ZA
dc.subject Mycoplasma genitalium en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Risk factors en_ZA
dc.title Genital Chlamydia trachomatis and Neisseria gonorrhoeae infections among women in sub-Saharan Africa : a structured review en_ZA
dc.type Postprint Article en_ZA

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