The potential use of leaf extracts of two Newtonia (Fabaceae) species to treat diarrhoea

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dc.contributor.author Motlhatlego, K.E.
dc.contributor.author Njoya, Emmanuel Mfotie
dc.contributor.author Abdalla, Muna Ali
dc.contributor.author Eloff, Jacobus Nicolaas
dc.contributor.author McGaw, Lyndy Joy
dc.date.accessioned 2018-06-21T08:48:38Z
dc.date.issued 2018-05
dc.description.abstract In southern Africa, many medicinal plants are used traditionally to treat gastrointestinal disorders and other infectious diseases. Newtonia hildebrandtii and Newtonia buchananii are used for the treatment of wounds and skin conditions, and for an upset stomach. Following promising unpublished antibacterial activity against Escherichia coli, this study was undertaken to evaluate the potential efficacy of N. hildebrandtii and N. buchananii extracts in treating diarrhoea. The antimicrobial activity of N. hildebrandtii and N. buchananii extracts was determined against a panel of Gram-positive and Gram-negative bacteria and two fungi implicated in causing diarrhoea. N. buchananii had strong antimicrobial effect against Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 20 μg/ml and moderate activity of 40 μg/ml against Bacillus cereus. Cytotoxicity of extracts was evaluated against Vero cells and both plants were relatively non-toxic with IC50 values of 30–750 μg/ml. Selectivity index values as high as 18.75 were reached with the methanol–dichloromethane leaf extract of N. buchananii. The extracts also had good anti-inflammatory and antioxidant activities as well as acetylcholinesterase inhibition efficacy. These activities are all useful adjuncts, together with antimicrobial effects, in potential plant-based remedies to be used as diarrhoea treatments. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.embargo 2019-05-01
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship The South African Medical Research Council (SIR JN Eloff), National Research Foundation (Unique Grant No 105993 LJ McGaw; PhD Scholarship KE Motlhatlego) and University of Pretoria. en_ZA
dc.description.uri http://www.elsevier.com/locate/sajb en_ZA
dc.identifier.citation Motlhatlego, K.E., Njoya, E.M., Abdalla, M.A. et al. 2018, 'The potential use of leaf extracts of two Newtonia (Fabaceae) species to treat diarrhoea', South African Journal of Botany, vol. 116, pp. 25-33. en_ZA
dc.identifier.issn 0254-6299 (print)
dc.identifier.issn 1727-9321 (online)
dc.identifier.other 10.1016/j.sajb.2018.02.395
dc.identifier.uri http://hdl.handle.net/2263/65196
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2018 SAAB. Published by Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in South African Journal of Botany. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in South African Journal of Botany, vol. 116, pp. 25-33, 2018. doi : 10.1016/j.sajb.2018.02.395. en_ZA
dc.subject Acetylcholinesterase en_ZA
dc.subject Anti-inflammatory en_ZA
dc.subject Cytotoxicity en_ZA
dc.subject Antimicrobial en_ZA
dc.subject Diarrhoea en_ZA
dc.subject Fabaceae en_ZA
dc.subject Newtonia en_ZA
dc.subject Enteric nervous system en_ZA
dc.subject Innate immunity en_ZA
dc.subject Bacteria en_ZA
dc.subject Assay en_ZA
dc.subject Macrophage en_ZA
dc.subject Antioxidant activity en_ZA
dc.subject Nitric oxide en_ZA
dc.subject Plant extracts en_ZA
dc.title The potential use of leaf extracts of two Newtonia (Fabaceae) species to treat diarrhoea en_ZA
dc.type Postprint Article en_ZA


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